Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 13/20 | 0.39 |
| ▸ | CTSK | P43235 | 13/20 | 0.39 |
| ▸ | CTSS | P25774 | 12/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CTSV | O60911 | 1/20 | 0.33 |
| ▸ | CTSB | P07858 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4319020 | 0.85 | CTSK (0.34) | CTSLCTSKCTSSCTSVCTSB | |
| SCHEMBL6236069 | 0.85 | SMN1; SMN2 (0.38) | CTSLCTSKCTSSSMN1; SMN2CTSV | |
| SCHEMBL6256603 | 0.84 | CTSK (0.37) | CTSLCTSKCTSSCTSVCTSB | |
| SCHEMBL4316698 | 0.81 | CTSL (0.33) | CTSLCTSKCTSSSMN1; SMN2 | |
| SCHEMBL6237797 | 0.80 | CTSL (0.43) | CTSLCTSKCTSSSMN1; SMN2CTSV | |
| SCHEMBL6258943 | 0.80 | CTSL (0.40) | CTSLCTSKCTSSCTSVCTSB | |
| SCHEMBL5099273 | 0.76 | CTSK (0.40) | CTSLCTSKCTSSCTSVCTSB | |
| SCHEMBL4310381 | 0.76 | CTSK (0.56) | CTSLCTSKCTSSCTSVCTSB | |
| SCHEMBL4323803 | 0.76 | CTSK (0.56) | CTSLCTSKCTSSCTSVCTSB | |
| SCHEMBL4316425 | 0.76 | CTSK (0.56) | CTSLCTSKCTSSCTSVCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005013909-A2 | NOVEL CATHEPSIN K INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-02-17 | — | — | WO | disclosed |