Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Zolpidem. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 4/20 | 0.83 |
| ▸ | GABRB1 known ✓ | P18505 | 1/20 | 0.83 |
| ▸ | GABRG2 known ✓ | P18507 | 1/20 | 0.83 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.83 |
| ▸ | ALB | P02768 | 2/20 | 0.83 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.83 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.83 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.83 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.83 |
| ▸ | LMNA | P02545 | 1/20 | 0.83 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.83 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.83 |
| ▸ | HPGD | P15428 | 1/20 | 0.83 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.83 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.83 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.83 |
| ▸ | HTR2B | P41595 | 1/20 | 0.83 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.83 |
| ▸ | TSPO | P30536 | 2/20 | 0.52 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Zolpidem SCHEMBL40721 | 0.99 | GABRB2 (0.85) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL7127421 | 0.99 | GABRB2 (0.85) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL1402195 | 0.99 | GABRB2 (0.85) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL30604720 | 0.99 | GABRB2 (0.85) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL29382172 | 0.99 | GABRB2 (0.85) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL8207467 | 0.99 | GABRB2 (0.85) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL17477 | 0.99 | GABRB2 (0.85) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL17004049 | 0.99 | GABRB2 (0.85) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL4753981 | 0.98 | GABRB2 (0.83) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL22685033 | 0.98 | GABRB2 (0.83) | GABRB2GABRA1ALBOPRK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3851418-A1 | METHOD AND SYSTEM FOR BIOLOGICAL TREATMENT OF HIGHLY CONCENTRATED WASTE WATER | Bluetector AG (CH) | 2021-07-21 | — | — | EP | disclosed |
| EP-1563822-B1 | Dental material based on alkoxysilyl functional polyether comprising a catalyst | KETTENBACH GMBH & CO KG (DE) | 2020-09-02 | — | — | EP | disclosed |
| WO-2015162163-A1 | COMBINED RECOVERY OF PHOSPHORUS, POTASSIUM AND NITROGEN FROM AQUEOUS RESIDUAL MATERIAL | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. (DE) | 2015-10-29 | — | — | WO | disclosed |
| EP-1563822-A2 | Dental material based on alkoxysilyl functional polyether comprising a catalyst | Kettenbach GmbH & CO. KG (DE) | 2005-08-17 | — | — | EP | disclosed |
| EP-1538213-A2 | Process for the fermentative preparation of L-amino acids using coryneform bacteria | Degussa AG (DE) | 2005-06-08 | — | — | EP | disclosed |
| EP-1529155-A1 | INTERNAL COMBUSTION ENGINE COMPRISING A REDUCING AGENT PRODUCTION UNIT AND OPERATING METHOD THEREFOR | DaimlerChrysler AG (DE) | 2005-05-11 | — | — | EP | disclosed |
| WO-2004022936-A1 | INTERNAL COMBUSTION ENGINE COMPRISING A REDUCING AGENT PRODUCTION UNIT AND OPERATING METHOD THEREFOR | DAIMLERCHRYSLER AG (DE) | 2004-03-18 | — | — | WO | disclosed |
| EP-0602516-B1 | Process for the chemical destruction of cured aminoplast resins | BASF AG (DE) | 1995-11-22 | — | — | EP | disclosed |
| EP-0602516-A1 | Process for the chemical destruction of cured aminoplast resins | BASF Aktiengesellschaft (DE) | 1994-06-22 | — | — | EP | disclosed |
| EP-0252329-B1 | PROCESS FOR REMOVAL OF NITROGEN OXIDES FROM WASTE GASES | WALTHER & CIE. AKTIENGESELLSCHAFT (DE) | 1990-01-24 | — | — | EP | disclosed |
| EP-0252329-A1 | Process for removal of nitrogen oxides from waste gases | WALTHER & CIE. AKTIENGESELLSCHAFT (DE) | 1988-01-13 | — | — | EP | disclosed |