Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB2 | Q9UBS0 | 7/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | GFER | P55789 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | ATM | Q13315 | 2/20 | 0.54 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.54 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19092124 | 0.79 | RPS6KB2 (0.64) | RPS6KB2KDM4EMAPTALDH1A1NPC1 | |
| SCHEMBL6234080 | 0.79 | RPS6KB2 (0.64) | RPS6KB2KDM4EMAPTALDH1A1NPC1 | |
| SCHEMBL16027135 | 0.79 | RPS6KB2 (0.74) | RPS6KB2KDM4EMAPTALDH1A1NPC1 | |
| SCHEMBL31393470 | 0.79 | RPS6KB2 (0.74) | RPS6KB2KDM4EMAPTALDH1A1NPC1 | |
| SCHEMBL6232602 | 0.78 | ABCG2 (0.55) | RPS6KB2KDM4EMAPTALDH1A1NPC1 | |
| SCHEMBL7692571 | 0.78 | RPS6KB2 (1.00) | RPS6KB2KDM4EMAPTALDH1A1NPC1 | |
| SCHEMBL28450107 | 0.78 | NPC1 (0.67) | KDM4EMAPTALDH1A1NPC1RAB9A | |
| SCHEMBL19066635 | 0.77 | RPS6KB2 (0.71) | RPS6KB2KDM4EMAPTALDH1A1NPC1 | |
| SCHEMBL6236081 | 0.77 | RPS6KB2 (0.70) | RPS6KB2KDM4EMAPTALDH1A1NPC1 | |
| SCHEMBL6239309 | 0.77 | RPS6KB2 (0.70) | RPS6KB2KDM4EMAPTALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12077527-B2 | Compositions and methods for inhibiting ACSS2 | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2024-09-03 | — | — | US | disclosed |
| US-20220117958-A1 | COMPOSITIONS AND METHODS FOR INHIBITING ACSS2 | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2022-04-21 | — | — | US | disclosed |
| US-20220117958-A1 | COMPOSITIONS AND METHODS FOR INHIBITING ACSS2 | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2022-04-21 | — | — | US | disclosed |
| EP-3856184-A1 | COMPOSITIONS AND METHODS FOR INHIBITING ACSS2 | The Trustees of the University of Pennsylvania (US) | 2021-08-04 | — | — | EP | disclosed |
| US-20200291005-A1 | COMPOSITIONS AND METHODS FOR INHIBITING ACSS2 | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2020-09-17 | — | — | US | disclosed |
| US-20200291005-A1 | COMPOSITIONS AND METHODS FOR INHIBITING ACSS2 | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2020-09-17 | — | — | US | disclosed |
| EP-3687628-A1 | COMPOSITIONS AND METHODS FOR INHIBITING ACSS2 | The Trustees of The University of Pennsylvania (US) | 2020-08-05 | — | — | EP | disclosed |
| WO-2020069093-A1 | COMPOSITIONS AND METHODS FOR INHIBITING ACSS2 | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2020-04-02 | — | — | WO | disclosed |
| WO-2019067528-A1 | COMPOSITIONS AND METHODS FOR INHIBITING ACSS2 | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2019-04-04 | — | — | WO | disclosed |
| WO-2019067528-A1 | COMPOSITIONS AND METHODS FOR INHIBITING ACSS2 | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2019-04-04 | — | — | WO | disclosed |
| WO-2005007099-A2 | PKB INHIBITORS AS ANTI-TUMOR AGENTS | IMCLONE SYSTEMS INCORPORATED (US) | 2005-01-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12077527-B2 | Compositions and methods for inhibiting ACSS2 | ACSS2, ACSL3, ACSL1 | RPS6KB2 1234/4885KDM4E 1131/4885MAPT 949/4885 |
| US-20200291005-A1 | COMPOSITIONS AND METHODS FOR INHIBITING ACSS2 | ACSS2, ACSL3, ACSL1 | RPS6KB2 1234/4885KDM4E 1131/4885MAPT 949/4885 |
| US-20220117958-A1 | COMPOSITIONS AND METHODS FOR INHIBITING ACSS2 | ACSS2, ACSL3, ACSL1 | RPS6KB2 1234/4885KDM4E 1131/4885MAPT 949/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.