Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 10/20 | 0.51 |
| ▸ | HTR7 | P34969 | 9/20 | 0.51 |
| ▸ | DRD2 | P14416 | 8/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6234661 | 0.86 | HTR1A (0.67) | HTR1AHTR7DRD2LMNAMAPT | |
| SCHEMBL6241268 | 0.83 | HTR1A (0.37) | HTR1AHTR7DRD2LMNAMAPT | |
| SCHEMBL6241149 | 0.83 | HTR1A (0.61) | HTR1AHTR7DRD2ADRA1B | |
| SCHEMBL4528441 | 0.78 | ADRA1D (0.53) | HTR1AHTR7DRD2HTR6ADRA1B | |
| Hydrochloric Acid SCHEMBL4534062 | 0.78 | ADRA1D (0.52) | HTR1AHTR7DRD2HTR6ADRA1B | |
| SCHEMBL4521352 | 0.77 | HTR1A (0.47) | HTR1AHTR7DRD2HTR6ADRA1B | |
| Hydrochloric Acid SCHEMBL4517586 | 0.76 | HTR1A (0.47) | HTR1AHTR7DRD2LMNAMAPT | |
| SCHEMBL6243936 | 0.76 | ADRA1B (0.54) | HTR1AHTR7DRD2LMNAMAPT | |
| Hydrochloric Acid SCHEMBL6209546 | 0.75 | ADRA1B (0.56) | HTR1AHTR7DRD2LMNAADRA1B | |
| SCHEMBL4522919 | 0.75 | HTR1A (0.42) | HTR1AHTR7DRD2HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005018643-A1 | METABOLITES OF 1-{3-4`4-(2-METHOXYPHENYL) PIPERAZIN-1-YL!-PROPYL}-PIPERIDINE-2, 6-DIONE FOR USE IN THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA | RANBAXY LABORATORIES LIMITED (IN) | 2005-03-03 | — | — | WO | claimed |
| WO-2005018643-A1 | METABOLITES OF 1-{3-4`4-(2-METHOXYPHENYL) PIPERAZIN-1-YL!-PROPYL}-PIPERIDINE-2, 6-DIONE FOR USE IN THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA | RANBAXY LABORATORIES LIMITED (IN) | 2005-03-03 | — | — | WO | disclosed |