Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4A | P47712 | 1/20 | 0.43 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | ITGB2 | P05107 | 8/20 | 0.42 |
| ▸ | ICAM1 | P05362 | 8/20 | 0.42 |
| ▸ | ITGAL | P20701 | 8/20 | 0.42 |
| ▸ | MIF | P14174 | 1/20 | 0.40 |
| ▸ | RHEB | Q15382 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.36 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6238628 | 1.00 | PLA2G4A (0.43) | PLA2G4APTGESITGB2ICAM1ITGAL | |
| SCHEMBL6817329 | 0.85 | ITGB2 (0.52) | PLA2G4APTGESITGB2ICAM1ITGAL | |
| SCHEMBL6568833 | 0.85 | ITGB2 (0.52) | PLA2G4APTGESITGB2ICAM1ITGAL | |
| SCHEMBL6759499 | 0.81 | PLA2G4A (0.54) | PLA2G4APTGESITGB2ICAM1ITGAL | |
| SCHEMBL6759492 | 0.81 | PLA2G4A (0.54) | PLA2G4APTGESITGB2ICAM1ITGAL | |
| SCHEMBL4278689 | 0.79 | MIF (0.44) | PLA2G4APTGESITGB2ICAM1ITGAL | |
| SCHEMBL4278685 | 0.79 | MIF (0.44) | PLA2G4APTGESITGB2ICAM1ITGAL | |
| SCHEMBL4277853 | 0.76 | PTGES (0.45) | PLA2G4APTGESITGB2ICAM1ITGAL | |
| SCHEMBL4277854 | 0.76 | PTGES (0.45) | PLA2G4APTGESITGB2ICAM1ITGAL | |
| SCHEMBL6316878 | 0.76 | ITGB2 (0.43) | PLA2G4APTGESITGB2ICAM1ITGAL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005019177-A1 | AMINOPIPERIDINE AMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-03-03 | — | — | WO | disclosed |