Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.37 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
| ▸ | AGXT | P21549 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6236176 | 1.00 | EPHX2 (0.38) | EPHX2NPC1RAB9AKMT2ACARM1 | |
| SCHEMBL8177812 | 0.88 | GRIK1 (0.44) | GRM2GRM3CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL3182056 | 0.88 | GRIK1 (0.44) | GRM2GRM3CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL30471875 | 0.86 | KCNH2 (0.46) | NPC1RAB9ACARM1PRMT6IDO1 | |
| SCHEMBL24928604 | 0.86 | KCNH2 (0.44) | EPHX2KCNH2CYP2C19ALDH1A1 | |
| SCHEMBL7385029 | 0.86 | KCNH2 (0.44) | EPHX2KCNH2CYP2C19ALDH1A1 | |
| SCHEMBL6238616 | 0.86 | KCNH2 (0.44) | EPHX2KCNH2CYP2C19ALDH1A1 | |
| SCHEMBL8151501 | 0.84 | P2RX3 (0.48) | EPHX2CARM1PRMT6ALDH1A1CYP3A4 | |
| SCHEMBL6239011 | 0.76 | IDO1 (0.40) | CARM1PRMT6IDO1AGXTSLC6A4 | |
| SCHEMBL6236177 | 0.76 | IDO1 (0.40) | CARM1PRMT6IDO1AGXTSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005011697-A2 | SULFONAMIDE DERIVATIVES WITH ACTIVITY ON PROTEIN KINASE A AND B | ASTEX THERAPEUTICS LIMITED (GB) | 2005-02-10 | — | — | WO | disclosed |