Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSD | A5PKW4 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | USP7 | Q93009 | 1/20 | 0.31 |
| ▸ | USP47 | Q96K76 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1746866 | 0.88 | CYP2A6 (0.40) | TDP1ALDH1A1MAPTPOLBMEN1 | |
| SCHEMBL6190813 | 0.78 | CNR2 (0.39) | PSDTDP1ALDH1A1SCN9ANOTUM | |
| SCHEMBL6192327 | 0.77 | ALDH1A1 (0.47) | TDP1ALDH1A1NOTUMTSHRMAPT | |
| SCHEMBL6195275 | 0.77 | ALDH1A1 (0.56) | TDP1ALDH1A1MAPTMEN1HPGD | |
| SCHEMBL15636896 | 0.76 | CNR2 (0.41) | SCN9APTGES2NOTUMCNR2TSHR | |
| SCHEMBL6193171 | 0.76 | PTPRC (0.41) | TDP1ALDH1A1MAPTPOLB | |
| SCHEMBL6194132 | 0.76 | MCL1 (0.41) | TDP1ALDH1A1MCL1TSHRCA1 | |
| SCHEMBL6190538 | 0.75 | TDP1 (0.50) | TDP1ALDH1A1TSHRDHODHMAPT | |
| SCHEMBL6187317 | 0.75 | AHR (0.47) | TDP1NOTUMTSHRMAPTPOLB | |
| SCHEMBL6232173 | 0.74 | ALDH1A1 (0.38) | TDP1ALDH1A1TSHRMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585727-A1 | INDOLES USEFUL IN THE TREATMENT OF ANDROGEN-RECEPTOR RELATED DISEASES | Akzo Nobel N.V. (NL) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004041782-A1 | INDOLES USEFUL IN THE TREATMENT OF ANDROGEN-RECEPTOR RELATED DISEASES | AKZO NOBEL N.V. (NL) | 2004-05-21 | — | — | WO | disclosed |