Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 7/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6239108 | 0.78 | PSD (0.34) | CNR2TDP1PDPK1PSDCA1 | |
| SCHEMBL6193406 | 0.76 | NPC1 (0.34) | CNR2TDP1MAPTALDH1A1 | |
| SCHEMBL711877 | 0.75 | ALDH1A1 (0.33) | TDP1ALDH1A1 | |
| SCHEMBL6501996 | 0.72 | CNR2 (0.41) | CNR2NOTUMCNR1DHODH | |
| SCHEMBL3542595 | 0.72 | POLB (0.43) | TDP1CA1CA2MAPTALDH1A1 | |
| SCHEMBL4451869 | 0.71 | HSD11B1 (0.35) | CNR2ALDH1A1 | |
| SCHEMBL2040645 | 0.69 | MAPK1 (0.41) | TDP1MAPTALDH1A1POLBMEN1 | |
| SCHEMBL2497558 | 0.68 | TSHR (0.45) | TDP1NOTUMHSP90AA1MAPTALDH1A1 | |
| SCHEMBL27515936 | 0.67 | FBP1 (0.39) | TDP1MAPTALDH1A1POLBNPSR1 | |
| SCHEMBL2495684 | 0.67 | S100A4 (0.56) | TDP1CA1CA2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585727-A1 | INDOLES USEFUL IN THE TREATMENT OF ANDROGEN-RECEPTOR RELATED DISEASES | Akzo Nobel N.V. (NL) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004041782-A1 | INDOLES USEFUL IN THE TREATMENT OF ANDROGEN-RECEPTOR RELATED DISEASES | AKZO NOBEL N.V. (NL) | 2004-05-21 | — | — | WO | disclosed |