Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 2/20 | 0.35 |
| ▸ | RXRB | P28702 | 2/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TTR | P02766 | 1/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.31 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.30 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6192327 | 0.88 | ALDH1A1 (0.47) | ALDH1A1TSHRTDP1MAPK1RXRA | |
| SCHEMBL6191703 | 0.88 | AHR (0.38) | ALDH1A1TSHRTDP1MAPK1CYP19A1 | |
| SCHEMBL6187317 | 0.83 | AHR (0.47) | TSHRTDP1MAPK1HSD17B10MEN1 | |
| SCHEMBL8650141 | 0.81 | CYP19A1 (0.35) | TSHRTDP1CYP19A1MEN1POLB | |
| SCHEMBL387257 | 0.81 | ALDH1A1 (0.44) | ALDH1A1TSHRTDP1MAPK1HSD17B10 | |
| SCHEMBL3296222 | 0.80 | CRHBP (0.49) | ALDH1A1TDP1MAPK1CYP19A1POLB | |
| SCHEMBL6191442 | 0.79 | PGR (0.37) | ALDH1A1TDP1CYP19A1MEN1POLB | |
| SCHEMBL9206594 | 0.79 | CA12 (0.44) | ALDH1A1TDP1MAPK1CYP19A1HSD17B10 | |
| SCHEMBL5631988 | 0.77 | HPRT1 (0.47) | ALDH1A1TSHRTDP1MAPK1HSD17B10 | |
| SCHEMBL15208829 | 0.77 | POLB (0.34) | ALDH1A1TDP1CYP19A1MEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585727-A1 | INDOLES USEFUL IN THE TREATMENT OF ANDROGEN-RECEPTOR RELATED DISEASES | Akzo Nobel N.V. (NL) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004041782-A1 | INDOLES USEFUL IN THE TREATMENT OF ANDROGEN-RECEPTOR RELATED DISEASES | AKZO NOBEL N.V. (NL) | 2004-05-21 | — | — | WO | disclosed |