Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 10/20 | 0.55 |
| ▸ | HNF4A | P41235 | 7/20 | 0.55 |
| ▸ | RARB | P10826 | 9/20 | 0.49 |
| ▸ | RARG | P13631 | 9/20 | 0.49 |
| ▸ | RARA | P10276 | 7/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
| ▸ | RXRG | P48443 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6243135 | 0.91 | RXRA (0.53) | RXRAHNF4ARARBRARGRARA | |
| SCHEMBL6240820 | 0.90 | RXRA (0.49) | RXRAHNF4ARARBRARGRARA | |
| SCHEMBL6242710 | 0.87 | HNF4A (0.41) | RXRAHNF4ARARBRARGRARA | |
| SCHEMBL6242411 | 0.86 | RXRA (0.50) | RXRAHNF4ARARBRARGRARA | |
| SCHEMBL6236927 | 0.85 | RARB (0.58) | RXRARARBRARGRARARXRB | |
| SCHEMBL6239783 | 0.85 | HNF4A (0.72) | RXRAHNF4ARARBRARGRARA | |
| SCHEMBL6239175 | 0.84 | RXRA (0.67) | RXRAHNF4ARARBRARGRARA | |
| SCHEMBL6244138 | 0.82 | RXRA (0.60) | RXRARARBRARGRARARXRB | |
| SCHEMBL6240826 | 0.82 | RXRA (0.58) | RXRAHNF4ARARBRARGRARA | |
| SCHEMBL6241853 | 0.81 | RARB (0.53) | RXRARARBRARGRARARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005017185-A2 | HEPATOCYTE NUCLEAR FACTOR 4α MODULATOR COMPOUNDS | LIGAND PHARMCEUTICALS INCORPORATED (US) | 2005-02-24 | — | — | WO | claimed |
| WO-2005016255-A2 | SUBSTITUTED TETRAHYDROQUINOLINES, PHENYLACETIC ACIDS AND BENZOIC ACIDS AS HEPATOCYTE NUCLEAR FACTOR 4 (HNF-4 ) MODULATOR COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2005-02-24 | — | — | WO | disclosed |
| WO-2005017185-A2 | HEPATOCYTE NUCLEAR FACTOR 4α MODULATOR COMPOUNDS | LIGAND PHARMCEUTICALS INCORPORATED (US) | 2005-02-24 | — | — | WO | disclosed |
| WO-2005010202-A2 | PHENYL ACETIC ACID DERIVATIVES AS HEPATOCYTE NUCLEAR FACTOR 4α (HNF-4α) MODULATOR COMPOUNDS | LIGAND PHARMACUETICALS INCORPORATED (US) | 2005-02-03 | — | — | WO | disclosed |