Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 9/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 8/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.37 |
| ▸ | CHRNA1 | P02708 | 3/20 | 0.37 |
| ▸ | CHRNG | P07510 | 1/20 | 0.37 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.37 |
| ▸ | CHRND | Q07001 | 1/20 | 0.37 |
| ▸ | CHRNA2 | Q15822 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4727579 | 1.00 | CHRNB2 (0.43) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNA1 | |
| SCHEMBL8550383 | 0.89 | GPR119 (0.37) | CHRNB2CHRNA3CHRNA4CHRNB4 | |
| SCHEMBL4727403 | 0.85 | CHRNB2 (0.48) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNA2 | |
| SCHEMBL6235429 | 0.83 | CHRNB2 (0.54) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNB1 | |
| SCHEMBL8554594 | 0.82 | CHRNB2 (0.41) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNA2 | |
| SCHEMBL8553258 | 0.82 | CHRNB2 (0.41) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNA2 | |
| SCHEMBL6231934 | 0.82 | CHRNB2 (0.48) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNA2 | |
| SCHEMBL4726517 | 0.82 | CHRNB2 (0.48) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNA2 | |
| SCHEMBL7406929 | 0.81 | CHRNB4 (0.36) | CHRNB2CHRNA3CHRNA4CHRNB4 | |
| SCHEMBL4962971 | 0.81 | CHRNB2 (0.49) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005000806-A2 | LIGANDS FOR NICOTINIC ACETYLCHOLINE RECEPTORS, AND METHODS OF MAKING AND USING THEM | GEORGETOWN UNIVERSITY (US) | 2005-01-06 | — | — | WO | disclosed |