Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 8/20 | 0.47 |
| ▸ | PIM1 | P11309 | 9/20 | 0.46 |
| ▸ | HASPIN | Q8TF76 | 2/20 | 0.43 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL624739 | 0.95 | PIM1 (0.47) | DYRK1APIM1HASPINKCNH2 | |
| SCHEMBL623206 | 0.95 | PIM1 (0.47) | DYRK1APIM1KCNH2 | |
| SCHEMBL626627 | 0.89 | PIM1 (0.45) | DYRK1APIM1KCNH2 | |
| SCHEMBL625254 | 0.87 | PIM3 (0.51) | DYRK1APIM1HASPINPIM3KCNH2 | |
| SCHEMBL625511 | 0.85 | PIM1 (0.45) | DYRK1APIM1HASPINKCNH2 | |
| SCHEMBL625248 | 0.84 | PIM2 (0.51) | DYRK1APIM1HASPINPIM3KCNH2 | |
| SCHEMBL623949 | 0.84 | PIM1 (0.47) | PIM1PIM3 | |
| SCHEMBL623866 | 0.81 | DYRK1A (0.48) | DYRK1APIM1KCNH2 | |
| SCHEMBL625560 | 0.81 | FYN (0.50) | PIM1PIM3KCNH2 | |
| SCHEMBL623995 | 0.80 | PIM1 (0.44) | DYRK1APIM1HASPINPIM3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |