Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM3 | Q86V86 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 8/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.46 |
| ▸ | HASPIN | Q8TF76 | 4/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL624739 | 0.88 | PIM1 (0.47) | PIM1DYRK1AHASPINKCNH2 | |
| SCHEMBL623948 | 0.87 | DYRK1A (0.47) | PIM3PIM1DYRK1AHASPINKCNH2 | |
| SCHEMBL623131 | 0.84 | PIM1 (0.61) | PIM3PIM1DYRK1AHASPINKCNH2 | |
| SCHEMBL623206 | 0.84 | PIM1 (0.47) | PIM1DYRK1AKCNH2 | |
| SCHEMBL625255 | 0.83 | PIM3 (0.48) | PIM3PIM1 | |
| SCHEMBL624449 | 0.83 | PIM1 (0.69) | PIM1DYRK1AKCNH2 | |
| SCHEMBL624481 | 0.82 | PIM1 (0.56) | PIM3PIM1DYRK1AHASPINKCNH2 | |
| SCHEMBL625511 | 0.81 | PIM1 (0.45) | PIM1DYRK1AHASPINKCNH2 | |
| SCHEMBL625248 | 0.81 | PIM2 (0.51) | PIM3PIM1DYRK1AHASPINKCNH2 | |
| SCHEMBL626627 | 0.79 | PIM1 (0.45) | PIM1DYRK1AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |