Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 3/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.34 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.34 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6239570 | 0.86 | ADAMTS4 (0.43) | ADAMTS4MMP13MMP1ADAM17KCNH2 | |
| SCHEMBL6241136 | 0.83 | GRIA4 (0.37) | MMP13ADAM17KCNH2GRIA4GRIA2 | |
| SCHEMBL6241979 | 0.79 | GRIA4 (0.51) | MMP13MMP1KCNH2GRIA4GRIA2 | |
| SCHEMBL6242089 | 0.78 | HRH3 (0.35) | MMP13GRIA4GRIA2 | |
| SCHEMBL6237718 | 0.78 | FDFT1 (0.49) | ADAMTS4MMP13KMT2A | |
| SCHEMBL6240728 | 0.77 | GRIA4 (0.39) | ADAMTS4MMP13MMP1ADAM17MAOB | |
| SCHEMBL6246315 | 0.77 | GRIA4 (0.45) | ADAMTS4MMP13MMP1KCNH2GRIA4 | |
| SCHEMBL6243776 | 0.76 | GRIA2 (0.36) | ADAMTS4MMP13MMP1ADAM17KCNH2 | |
| SCHEMBL6240219 | 0.76 | GRIA2 (0.42) | ADAMTS4KCNH2GRIA4GRIA2 | |
| SCHEMBL6242553 | 0.75 | ALDH1A1 (0.41) | GRIA4KMT2AALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1395550-B1 | CYCLOALKENYLSULFONAMIDE DERIVATIVES | LILLY CO ELI (US) | 2005-06-29 | — | — | EP | claimed |
| US-20040157817-A1 | Cycloalkenylsulfonamide derivatives | CANTELL BUDDY EUGENE (US) | 2004-08-12 | — | — | US | claimed |
| EP-1395550-A1 | CYCLOALKENYLSULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2004-03-10 | — | — | EP | claimed |
| WO-2002098847-A1 | CYCLOALKENYLSULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2002-12-12 | — | — | WO | claimed |
| EP-1395550-B1 | CYCLOALKENYLSULFONAMIDE DERIVATIVES | LILLY CO ELI (US) | 2005-06-29 | — | — | EP | disclosed |
| US-20040157817-A1 | Cycloalkenylsulfonamide derivatives | CANTELL BUDDY EUGENE (US) | 2004-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040157817-A1 | Cycloalkenylsulfonamide derivatives | GRIN2B, GRIN2A, GRIN1 | ADAMTS4 3846/4885MMP13 4825/4885MMP1 4848/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.