Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 8/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.36 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.36 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.34 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 5/20 | 0.31 |
| ▸ | MMP1 | P03956 | 4/20 | 0.31 |
| ▸ | MMP9 | P14780 | 4/20 | 0.31 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.31 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.31 |
| ▸ | MMP7 | P09237 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 1/20 | 0.31 |
| ▸ | MMP14 | P50281 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6241136 | 0.94 | GRIA4 (0.37) | GRIA2KCNH2GRIA4GRIA1GRIA3 | |
| SCHEMBL6243784 | 0.83 | CYP11B1 (0.36) | CSNK1EALDH1A1LMNAGAAGPR119 | |
| SCHEMBL6239993 | 0.83 | MMP2 (0.34) | GRIA2KCNH2ALDH1A1LMNAGAA | |
| SCHEMBL6242831 | 0.82 | GRIA2 (0.52) | GRIA2KCNH2GRIA4GRIA1GRIA3 | |
| SCHEMBL6242856 | 0.82 | ALDH1A1 (0.37) | KCNH2ALDH1A1LMNA | |
| SCHEMBL6237718 | 0.81 | FDFT1 (0.49) | MMP13ADAMTS4 | |
| SCHEMBL6242487 | 0.81 | ALDH1A1 (0.46) | GRIA4ALDH1A1LMNA | |
| SCHEMBL6240540 | 0.79 | ADAM17 (0.41) | GRIA2GRIA4MMP13MMP1MMP9 | |
| SCHEMBL6241141 | 0.78 | CYP11B1 (0.35) | CSNK1EALDH1A1LMNAGAA | |
| SCHEMBL6242243 | 0.77 | CXCR2 (0.37) | GRIA2GRIA4ADAMTS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1395550-B1 | CYCLOALKENYLSULFONAMIDE DERIVATIVES | LILLY CO ELI (US) | 2005-06-29 | — | — | EP | disclosed |
| US-20040157817-A1 | Cycloalkenylsulfonamide derivatives | CANTELL BUDDY EUGENE (US) | 2004-08-12 | — | — | US | disclosed |
| EP-1395550-A1 | CYCLOALKENYLSULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2004-03-10 | — | — | EP | disclosed |
| WO-2002098847-A1 | CYCLOALKENYLSULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2002-12-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040157817-A1 | Cycloalkenylsulfonamide derivatives | GRIN2B, GRIN2A, GRIN1 | GRIA2 7/4885KCNH2 552/4885GRIA4 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.