Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | NOS1 | P29475 | 4/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | NOS3 | P29474 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28425336 | 0.84 | NPC1 (0.45) | TSHRNPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL1177204 | 0.82 | TSHR (0.57) | TSHRALDH1A1MEN1CRHBPKMT2A | |
| SCHEMBL6037591 | 0.81 | ESR1 (0.41) | TSHRALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL7493116 | 0.80 | RORC (0.43) | TSHRNPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL11291473 | 0.80 | ALDH1A1 (0.62) | TSHRNPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL28100013 | 0.79 | ALDH1A1 (0.54) | TSHRALDH1A1MEN1KMT2AGAA | |
| SCHEMBL6792424 | 0.75 | TSHR (0.49) | TSHRALDH1A1MEN1CRHBPKMT2A | |
| SCHEMBL4162102 | 0.74 | TSHR (0.55) | TSHRALDH1A1MEN1CRHBPKMT2A | |
| SCHEMBL6037517 | 0.73 | ESR1 (0.41) | NPC1RAB9AALDH1A1ATMHSD17B10 | |
| SCHEMBL15659596 | 0.73 | TSHR (0.53) | TSHRALDH1A1MEN1CRHBPKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005021721-A2 | CARBOXYLESTERASE INHIBITORS | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2005-03-10 | — | — | WO | claimed |