Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.56 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.56 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.56 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.56 |
| ▸ | CYP4B1 | P13584 | 1/20 | 0.56 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.56 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.56 |
| ▸ | CYP2A7 | P20853 | 1/20 | 0.56 |
| ▸ | CYP3A7 | P24462 | 1/20 | 0.56 |
| ▸ | CYP2F1 | P24903 | 1/20 | 0.56 |
| ▸ | CYP2C18 | P33260 | 1/20 | 0.56 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.56 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12900885 | 0.88 | LMNA (0.52) | KMT2ACYP1A2CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL8307066 | 0.87 | KMT2A (0.56) | KMT2AMAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL6642702 | 0.86 | CYP1A2 (0.54) | CYP1A2CYP1A1CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL12836646 | 0.86 | CA1 (0.61) | KMT2ACYP1A2CYP1A1CYP2D6CYP2C9 | |
| SCHEMBL4085836 | 0.84 | HSD17B1 (0.64) | KMT2ACYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL2560248 | 0.84 | CA12 (0.59) | KDM4EMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL5944300 | 0.83 | CA1 (0.63) | CYP1A2CYP1A1CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL10922062 | 0.83 | CYP2C19 (0.55) | KMT2ACYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL17599105 | 0.82 | CYP1A1 (0.71) | CYP1A2CYP1A1CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL18800722 | 0.82 | NPC1 (0.54) | KMT2ACYP1A2CYP1A1CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050043381-A1 | Aminopyrazole compounds | AGOURON PHARMACEUTICALS, INC. | 2005-02-24 | — | — | US | disclosed |
| WO-2005009435-A1 | AMINOPYRAZOLE COMPOUNDS AND USE AS CHK1 INHIBITORS | PFIZER INC. (US) | 2005-02-03 | — | — | WO | disclosed |
| US-5972959-A | Oxime derivatives, their preparation and their therapeutic use | SANKYO COMPANY, LIMITED (JP) | 1999-10-26 | — | — | US | disclosed |
| EP-0708098-B1 | Oxime derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 1999-03-03 | — | — | EP | disclosed |
| US-5780490-A | A O-(2,4-OXA(OR THIA)ZOLIDINYL)PHENYLOXY(OR THIO OR AMINO) ALKYLOXIME; ALDOSE REDUCTASE INHIBITORS; ANTIDIABETIC AND -HYPOGLYCEMIC AGENTS; LIVER, SKIN AND UROGENITAL DISORDERS | SANKYO COMPANY, LIMITED (JP) | 1998-07-14 | — | — | US | disclosed |
| US-5703096-A | ANTIDIABETIC AGENTS; ALDOSE REDUCTASE INHIBITOR | SANKYO COMPANY, LIMITED (JP) | 1997-12-30 | — | — | US | disclosed |
| EP-0708098-A1 | Oxime derivatives, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1996-04-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043381-A1 | Aminopyrazole compounds | CDK1, CDK3, BUB1B | KMT2A 752/4885CYP1A2 1566/4885CYP1A1 1672/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.