Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2RL1 | P55085 | 14/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.41 |
| ▸ | FPR2 | P25090 | 2/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6239951 | 0.88 | MRGPRX4 (0.41) | F2RL1MRGPRX4FPR2PDE2A | |
| SCHEMBL6192150 | 0.86 | FPR2 (0.41) | F2RL1MRGPRX4FPR2 | |
| SCHEMBL6956313 | 0.80 | F2RL1 (0.50) | F2RL1 | |
| SCHEMBL6194278 | 0.75 | NPC1 (0.40) | F2RL1FPR2 | |
| SCHEMBL6193871 | 0.73 | FPR2 (0.38) | F2RL1MRGPRX4FPR2 | |
| SCHEMBL6955109 | 0.72 | F2RL1 (0.51) | F2RL1 | |
| SCHEMBL6193535 | 0.71 | FPR2 (0.38) | F2RL1MRGPRX4FPR2 | |
| SCHEMBL29256553 | 0.70 | PDE2A (0.51) | PDE2AJAK2JAK1TYK2 | |
| SCHEMBL29256552 | 0.70 | PDE2A (0.51) | PDE2AJAK2JAK1TYK2 | |
| SCHEMBL6193920 | 0.69 | MEN1 (0.39) | F2RL1FPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1450901-A4 | (1-PHENYL-2-HETEROARYL)ETHYL-GUANIDINE COMPOUNDS AS INHIBITORS OF MITOCHONDRIAL F1F0 ATP HYDROLASE | BRISTOL MYERS SQUIBB CO (US) | 2005-05-25 | — | — | EP | disclosed |
| EP-1450901-A2 | (1-PHENYL-2-HETEROARYL)ETHYL-GUANIDINE COMPOUNDS AS INHIBITORS OF MITOCHONDRIAL F1F0 ATP HYDROLASE | Bristol-Myers Squibb Company (US) | 2004-09-01 | — | — | EP | disclosed |
| WO-2003050261-A2 | (1-PHENYL-2-HETEROARYL)ETHYL-GUANIDINE COMPOUNDS AS INHIBITORS OF MITOCHONDRIAL F1F0 ATP HYDROLASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-06-19 | — | — | WO | disclosed |