Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 14/20 | 0.56 |
| ▸ | ADAM17 | P78536 | 10/20 | 0.56 |
| ▸ | MMP13 | P45452 | 3/20 | 0.56 |
| ▸ | MMP8 | P22894 | 4/20 | 0.51 |
| ▸ | MMP3 | P08254 | 2/20 | 0.51 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP14 | P50281 | 1/20 | 0.46 |
| ▸ | ADAM33 | Q9BZ11 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6239466 | 0.92 | MMP1 (0.57) | MMP1ADAM17MMP13MMP8MMP3 | |
| SCHEMBL6238225 | 0.85 | MMP1 (0.70) | MMP1ADAM17MMP13MMP8MMP3 | |
| SCHEMBL6237846 | 0.85 | MMP1 (0.70) | MMP1ADAM17MMP13MMP8MMP3 | |
| SCHEMBL6235947 | 0.82 | MMP1 (0.58) | MMP1ADAM17MMP13MMP8MMP3 | |
| SCHEMBL5760495 | 0.82 | ADAM17 (0.61) | MMP1ADAM17MMP13MMP8MMP3 | |
| SCHEMBL6238727 | 0.80 | MMP1 (0.54) | MMP1ADAM17MMP13MMP8MMP3 | |
| SCHEMBL6241133 | 0.80 | MMP1 (0.54) | MMP1ADAM17MMP13MMP8MMP3 | |
| SCHEMBL6238179 | 0.80 | MMP1 (0.54) | MMP1ADAM17MMP13MMP8MMP3 | |
| SCHEMBL6244304 | 0.79 | MMP1 (0.55) | MMP1ADAM17MMP13MMP8MMP3 | |
| SCHEMBL6240359 | 0.79 | MMP1 (0.53) | MMP1ADAM17MMP13MMP8MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1104412-B1 | TACE INHIBITORS | PFIZER PROD INC (US) | 2005-06-15 | — | — | EP | claimed |