Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MGAM | O43451 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SI | P14410 | 1/20 | 0.43 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4232151 | 0.98 | KMT2A (0.47) | KMT2ATDP1MEN1MGAMGAA | |
| Bromide SCHEMBL344154 | 0.96 | KMT2A (0.50) | KMT2ATDP1MEN1MGAMGAA | |
| SCHEMBL8968502 | 0.84 | GLA (0.44) | KMT2AMEN1GLAALDH1A1POLB | |
| SCHEMBL25583582 | 0.83 | GAA (0.48) | KMT2ATDP1MGAMGAASI | |
| SCHEMBL19037385 | 0.81 | KMT2A (0.45) | KMT2ATDP1MEN1HSP90AA1ALDH1A1 | |
| Bromide SCHEMBL16100576 | 0.81 | KMT2A (0.45) | KMT2AMEN1MGAMGAASI | |
| Hydrochloric Acid SCHEMBL5848674 | 0.79 | HSP90AA1 (0.50) | KMT2AMEN1HSP90AA1ALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL11424376 | 0.79 | ATM (0.55) | KMT2AGLAALDH1A1 | |
| Hydrochloric Acid SCHEMBL9742108 | 0.79 | NAAA (0.53) | KMT2AMEN1ALDH1A1ACHESMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL19031290 | 0.79 | KMT2A (0.47) | KMT2AMEN1HSP90AA1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12404274-B2 | Macrocycles as factor xia inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2025-09-02 | — | — | US | disclosed |
| CN-107973809-B | Macrocyclic compounds as factor XIA inhibitors | 百时美施贵宝公司 | 2023-06-30 | — | — | CN | disclosed |
| US-20230058729-A1 | MACROCYCLES AS FACTOR XIA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2023-02-23 | — | — | US | disclosed |
| US-11136327-B2 | Macrocycles as factor XIA inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-10-05 | — | — | US | disclosed |
| EP-3786165-A1 | SYNTHETIC INTERMEDIATES FOR PRODUCING MACROCYCLES AS FACTOR XIA INHIBITORS | Bristol-Myers Squibb Company (US) | 2021-03-03 | — | — | EP | disclosed |
| EP-2534154-B1 | MACROCYCLES AS FACTOR XIA INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2020-08-05 | — | — | EP | disclosed |
| US-20200087312-A1 | MACROCYCLES AS FACTOR XIA INHIBITORS | BRISTOL MYERS SQUIBB (US) | 2020-03-19 | — | — | US | disclosed |
| EP-2534152-B1 | MACROCYCLES AS FACTOR XIA INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-05-02 | — | — | EP | disclosed |
| US-20180022753-A1 | MACROCYCLES AS FACTOR XIA INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-01-25 | — | — | US | disclosed |
| US-9802939-B2 | Macrocycles as factor XIa inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-10-31 | — | — | US | disclosed |
| EP-0655997-A1 | PYRIDINIUM INTERMEDIATES AND THE PROCESS FOR PREPARING THE SAME. | ABBOTT LAB (US) | 1995-06-07 | — | — | EP | disclosed |
| EP-0602069-A4 | RETROVIRAL PROTEASE INHIBITORS. | SMITHKLINE BEECHAM CORP (US) | 1995-05-03 | — | — | EP | disclosed |
| EP-0655997-A4 | PYRIDINIUM INTERMEDIATES AND THE PROCESS FOR PREPARING THE SAME. | ABBOTT LAB (US) | 1995-02-10 | — | — | EP | disclosed |
| EP-0602069-A1 | RETROVIRAL PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-06-22 | — | — | EP | disclosed |
| US-5322845-A | Controlling plant diseases | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1994-06-21 | — | — | US | disclosed |
| US-5294721-A | Reacting a halonitrobenzene and a pyridinium salt | ABBOTT LABORATORIES (US) | 1994-03-15 | — | — | US | disclosed |
| WO-1994004502-A1 | PYRIDINIUM INTERMEDIATES AND THE PROCESS FOR PREPARING THE SAME | ABBOTT LABORATORIES (US) | 1994-03-03 | — | — | WO | disclosed |
| EP-0535980-A1 | 2-Pyridone derivatives, a process for their preparation and their use as fungicides | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1993-04-07 | — | — | EP | disclosed |
| US-4228230-A | Ultrasonic imaging of internally fogged silver halide elements | EASTMAN KODAK COMPANY (US) | 1980-10-14 | — | — | US | disclosed |
| US-3937712-A | MICROBIOCIDES | BOEHRINGER INGELHEIM GMBH (DT) | 1976-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200087312-A1 | MACROCYCLES AS FACTOR XIA INHIBITORS | TFPI, TFPI2, F11 | ACHE 3298/4885KMT2A 1111/4885TDP1 2393/4885 |
| US-12404274-B2 | Macrocycles as factor xia inhibitors | TFPI, TFPI2, F11 | ACHE 3298/4885KMT2A 1111/4885TDP1 2393/4885 |
| US-11136327-B2 | Macrocycles as factor XIA inhibitors | TFPI, TFPI2, F11 | ACHE 3298/4885KMT2A 1111/4885TDP1 2393/4885 |
| US-20180022753-A1 | MACROCYCLES AS FACTOR XIA INHIBITORS | TFPI, TFPI2, F11 | ACHE 3298/4885KMT2A 1111/4885TDP1 2393/4885 |
| US-20230058729-A1 | MACROCYCLES AS FACTOR XIA INHIBITORS | TFPI, TFPI2, F11 | ACHE 3298/4885KMT2A 1111/4885TDP1 2393/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.