SCHEMBL624565

SCHEMBL624565

NCc1cccc(CNC(=O)C(Cl)(Cl)Cl)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.51
CYP2D6 P10635 1/20 0.51
CYP2C9 P11712 1/20 0.51
TSHR P16473 1/20 0.51
CYP2C19 P33261 1/20 0.51
CFD P00746 1/20 0.47
TPSAB1 Q15661 3/20 0.46
AOC3 Q16853 2/20 0.44
HTR2C P28335 1/20 0.44
ALDH1A1 P00352 2/20 0.44
LOXL2 Q9Y4K0 1/20 0.44
HPGD P15428 1/20 0.44
HRH3 Q9Y5N1 1/20 0.43
KLKB1 P03952 1/20 0.43
KLK1 P06870 1/20 0.43
FPR3 P25089 1/20 0.43
FPR2 P25090 1/20 0.43
PNMT P11086 1/20 0.42
ENPP2 Q13822 1/20 0.42
NPC1 O15118 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL624727 0.87 CYP2C19 (0.49) CYP1A2CYP2D6CYP2C9TSHRCYP2C19
SCHEMBL625014 0.86 TPSAB1 (0.61) CYP1A2CYP2D6CYP2C9TSHRCYP2C19
SCHEMBL5834744 0.84 CYP1A2 (0.51) CYP1A2CYP2D6CYP2C9TSHRCYP2C19
SCHEMBL15680103 0.83 CYP1A2 (0.50) CYP1A2CYP2D6CYP2C9TSHRCYP2C19
SCHEMBL10071127 0.81 TACR1 (0.39) CYP1A2CYP2D6CYP2C9TSHRCYP2C19
SCHEMBL1500540 0.80 CYP1A2 (0.79) CYP1A2CYP2D6CYP2C9TSHRCYP2C19
SCHEMBL7041171 0.80 CYP2C9 (0.58) CYP1A2CYP2D6CYP2C9TSHRCYP2C19
SCHEMBL181282 0.79 RIPK1 (0.61) CYP1A2CYP2D6CYP2C9TSHRCYP2C19
SCHEMBL31168314 0.78 CYP1A2 (0.56) CYP1A2CYP2D6CYP2C9TSHRCYP2C19
SCHEMBL4927953 0.78 CYP1A2 (0.56) CYP1A2CYP2D6CYP2C9TSHRCYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012020221-A1 COMPOUNDS NOVACTA BIOSYSTEMS LIMITED (GB) 2012-02-16 WO disclosed
WO-2012020221-A1 COMPOUNDS NOVACTA BIOSYSTEMS LIMITED (GB) 2012-02-16 WO disclosed