SCHEMBL62458

SCHEMBL62458

O=Cc1c(F)cccc1Br

nearest known ligand 0.46

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MAOB P27338 2/20 0.46
ERN1 O75460 3/20 0.42
ALDH1A1 P00352 2/20 0.39
KMT2A Q03164 2/20 0.39
TDP1 Q9NUW8 2/20 0.39
MEN1 O00255 1/20 0.39
NFE2L2 Q16236 2/20 0.39
IKBKB O14920 1/20 0.37
HTT P42858 1/20 0.36
CYP2A6 P11509 1/20 0.36
CES2 O00748 1/20 0.34
CES1 P23141 1/20 0.34
ABCG2 Q9UNQ0 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31057535 1.00 MAOB (0.46) MAOBERN1ALDH1A1KMT2ATDP1
SCHEMBL2317333 0.86 ALDH1A1 (0.43) MAOBERN1ALDH1A1NFE2L2
SCHEMBL610877 0.83 ALDH1A1 (0.48) MAOBERN1ALDH1A1KMT2ATDP1
SCHEMBL95708 0.83 ERN1 (0.50) ERN1ALDH1A1KMT2ATDP1MEN1
SCHEMBL3059913 0.78 MAOB (0.34) MAOB
SCHEMBL29057998 0.78 MAOB (0.38) MAOBERN1ALDH1A1KMT2ATDP1
SCHEMBL29947357 0.77 MAOB (0.42) MAOBKMT2ATDP1NFE2L2IKBKB
SCHEMBL22579195 0.77 MAOB (0.42) MAOBALDH1A1KMT2ATDP1NFE2L2
SCHEMBL1986111 0.77 MAOB (0.42) MAOBKMT2ATDP1NFE2L2IKBKB
SCHEMBL3272039 0.77 ERN1 (0.35) MAOBERN1ALDH1A1KMT2ATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 612 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025262596-A1 METHODS OF MAKING OSIVELOTOR PFIZER INC. (US) 2025-12-26 WO claimed
CN-116425716-A Preparation method of epinastine intermediate 南京艾德凯腾生物医药有限责任公司 2023-07-14 CN claimed
CN-110818679-B Synthetic method of 4-bromobenzo [ b ] thiophene 苏州诚和医药化学有限公司 2022-04-12 CN claimed
CN-111004211-B Synthetic method of brexpiprazole intermediate 4-bromobenzo [ b ] thiophene 苏州诚和医药化学有限公司 2021-04-02 CN claimed
CN-111004211-A Synthetic method of brexpiprazole intermediate 4-bromobenzo [ b ] thiophene 苏州诚和医药化学有限公司 2020-04-14 CN claimed
CN-110818679-A Synthetic method of 4-bromobenzo [ b ] thiophene 苏州诚和医药化学有限公司 2020-02-21 CN claimed
CN-108440388-B The preparation method of one kind (S) -4- ((the bromo- 6- fluorophenyl of 2-) hydroxymethyl) piperidines -1- t-butyl formate 上海再启生物技术有限公司 2019-06-11 CN claimed
CN-108440388-A The preparation method of one kind (S) -4- ((the bromo- 6- fluorophenyls of 2-) hydroxymethyl) piperidines -1- t-butyl formates 上海再启生物技术有限公司 2018-08-24 CN claimed
CN-102070420-B Method for preparing 2-bromo-6-fluorobenzaldehyde UNIV CHANGZHOU 2013-12-18 CN claimed
CN-103113202-A (2E, 5E)-2, 5-benzal cyclopentanone analogue and preparation method and application thereof UNIV MUDANJIANG MEDICAL 2013-05-22 CN claimed
CN-103044224-A Penta-1,4-diene-3-ketone analogue and preparation method and application thereof UNIV MUDANJIANG MEDICAL 2013-04-17 CN claimed
CN-103044322-A (3E, 5E)-3,5-bipiperidyl-4-ketone analogue and preparation method and application thereof UNIV MUDANJIANG MEDICAL 2013-04-17 CN claimed
CN-103044227-A (2E, 6E)-2,6-bis(benzylidene)cyclohexanone analogue and preparation method and application thereof UNIV MUDANJIANG MEDICAL 2013-04-17 CN claimed
CN-102070420-A Method for preparing 2-bromo-6-fluorobenzaldehyde UNIV CHANGZHOU 2011-05-25 CN claimed
CN-117177975-B Pyrimido [5,4, D ] pyrimidine compounds, compositions comprising the same and uses thereof 蒙特利尔大学 2026-05-19 CN disclosed
US-20260109716-A1 CEREBLON-BASED KRAS DEGRADING PROTACS AND USES RELATED THERETO ARVINAS OPERATIONS, INC. (US) 2026-04-23 US disclosed
US-12577239-B2 Sulfilimines or sulfoximines containing fungicidal heterocyclic compounds PI INDUSTRIES LTD. (IN) 2026-03-17 US disclosed
EP-1153909-A2 Ortho-substituted benzaldehydes, process for their preparation, and their use Clariant GmbH (DE) 2001-11-14 EP disclosed
WO-2001068653-A1 DIHYDROIMIDAZO[2,1-B]THIAZOLE AND DIHYDRO-5H-THIAZOLO[3,2-A]PYRIMIDINES AS ANTIDEPRESSANT AGENTS KNOLL GMBH (DE) 2001-09-20 WO disclosed
CN-1231661-A Lactams and imides of aralkyl and arylalkylene heterocycles PFIZER (US) 1999-10-13 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260109716-A1 CEREBLON-BASED KRAS DEGRADING PROTACS AND USES RELATED THERETO KRAS, CRBN, HRAS MAOB 4825/4885ERN1 1739/4885ALDH1A1 3268/4885
US-12577239-B2 Sulfilimines or sulfoximines containing fungicidal heterocyclic compounds SULT1E1, CBR1, SULT1A1 MAOB 778/4885ERN1 1731/4885ALDH1A1 159/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.