Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.68 |
| ▸ | TAAR1 | Q96RJ0 | 6/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.55 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7211179 | 0.98 | SIGMAR1 (0.66) | SIGMAR1TAAR1HRH3CYP1A2CYP2A6 | |
| SCHEMBL3811751 | 0.83 | SIGMAR1 (0.57) | SIGMAR1HRH3CYP1A2CYP2A6PYCR1 | |
| SCHEMBL6543524 | 0.82 | SIGMAR1 (0.65) | SIGMAR1HRH3CYP1A2CYP2A6PYCR1 | |
| SCHEMBL12251063 | 0.82 | SIGMAR1 (0.60) | SIGMAR1HRH3CYP1A2CYP2A6PYCR1 | |
| Hydrochloric Acid SCHEMBL3809931 | 0.81 | SIGMAR1 (0.55) | SIGMAR1HRH3CYP1A2CYP2A6PYCR1 | |
| SCHEMBL29560700 | 0.80 | CYP1A2 (0.65) | SIGMAR1HRH3CYP1A2CYP2A6 | |
| SCHEMBL6240981 | 0.80 | CYP1A2 (0.65) | SIGMAR1HRH3CYP1A2CYP2A6 | |
| Hydrochloric Acid SCHEMBL11279264 | 0.79 | HRH3 (0.51) | SIGMAR1TAAR1HRH3CYP1A2 | |
| SCHEMBL17447228 | 0.79 | PYCR1 (0.61) | SIGMAR1TAAR1HRH3CYP1A2CYP2A6 | |
| SCHEMBL9670224 | 0.79 | SIGMAR1 (0.67) | SIGMAR1HRH3BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1070048-A4 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2001-11-07 | — | — | EP | claimed |
| EP-1070048-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-01-24 | — | — | EP | claimed |
| WO-1999051569-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-10-14 | — | — | WO | claimed |
| WO-2005030746-A1 | CALCILYTIC COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2005-04-07 | — | — | WO | disclosed |
| WO-2004069793-A2 | NOVEL 2-SUBSTITUTED CYCLIC AMINES AS CALCIUM SENSING RECEPTOR MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-08-19 | — | — | WO | disclosed |
| EP-1148876-A4 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2003-07-23 | — | — | EP | disclosed |
| WO-2002072760-A2 | PCRA HELICASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-09-19 | — | — | WO | disclosed |
| EP-1070048-A4 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2001-11-07 | — | — | EP | disclosed |
| EP-1148876-A1 | CALCILYTIC COMPOUNDS | SmithKline Beecham Corporation (US) | 2001-10-31 | — | — | EP | disclosed |
| EP-1070048-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-01-24 | — | — | EP | disclosed |
| WO-2000045816-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (GB) | 2000-08-10 | — | — | WO | disclosed |
| EP-0973730-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-01-26 | — | — | EP | disclosed |
| WO-1999051569-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-10-14 | — | — | WO | disclosed |
| EP-0901459-A1 | CALCILYTIC COMPOUNDS | NPS PHARMACEUTICALS, INC. (US) | 1999-03-17 | — | — | EP | disclosed |
| WO-1998045255-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-10-15 | — | — | WO | disclosed |
| WO-1997037967-A1 | CALCILYTIC COMPOUNDS | NPS PHARMACEUTICALS, INC. (US) | 1997-10-16 | — | — | WO | disclosed |