Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | MLYCD | O95822 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | FDPS | P14324 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.37 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8593179 | 0.87 | MLYCD (0.46) | ALOX5MLYCDNPSR1FDPSALDH1A1 | |
| SCHEMBL6873284 | 0.84 | MAPK1 (0.48) | ALDH1A1CYP1A2HPGDMAPK1 | |
| SCHEMBL6881357 | 0.81 | ALDH1A1 (0.54) | ALDH1A1LMNAMAP4K4HPGDTP53 | |
| SCHEMBL5847814 | 0.80 | ALDH1A1 (0.34) | ALOX5ALDH1A1CYP1A2CYP2C19MAPT | |
| SCHEMBL7579726 | 0.79 | MLYCD (0.40) | ALOX5MLYCDNPSR1FDPSALDH1A1 | |
| SCHEMBL6241847 | 0.79 | HSD17B10 (0.53) | MLYCDNPSR1LMNAHPGDTP53 | |
| SCHEMBL7476649 | 0.78 | HDAC6 (0.46) | ALOX15 | |
| SCHEMBL7145325 | 0.77 | NPC1 (0.67) | LMNAHPGDTP53 | |
| SCHEMBL6263800 | 0.77 | LMNA (0.41) | ALDH1A1LMNA | |
| SCHEMBL5847247 | 0.77 | ALDH1A1 (0.33) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268463-B1 | POLYCYCLIC ARYL AND HETEROARYL SUBSTITUTED 4-PYRONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | PHARMACIA CORP (US) | 2005-02-16 | — | — | EP | claimed |
| JP-2004505014-A | — | — | 2004-02-19 | — | — | JP | claimed |
| US-6693121-B2 | AS INHIBITORS OF SERINE PROTEASES OF THE COAGULATION CASCADE AND COMPOUNDS, USED FOR ANTICOAGULANT THERAPY FORPROPHYLAXIS OF A VARIETY OF THROMBOTIC CONDITIONS INCLUDING CORONARY ARTERY AND CEREBROVASCULAR DISEASES | PHARMACIA CORPORATION | 2004-02-17 | — | — | US | claimed |
| US-20030236257-A1 | Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the cogulation cascade | PHARMACIA CORPORATION | 2003-12-25 | — | — | US | claimed |
| EP-1268463-A2 | POLYCYCLIC ARYL AND HETEROARYL SUBSTITUTED 4-PYRONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | Pharmacia Corporation (US) | 2003-01-02 | — | — | EP | claimed |
| US-20020032174-A1 | Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade | PHARMACIA CORPORATION | 2002-03-14 | — | — | US | claimed |
| WO-2001077097-A2 | POLYCYCLIC ARYL AND HETEROARYL SUBSTITUTED 4-PYRONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | PHARMACIA CORPORATION (US) | 2001-10-18 | — | — | WO | claimed |
| WO-2001068605-A1 | POLYCYCLIC ARYL AND HETEROARYL SUBSTITUTED BENZENES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | PHARMACIA CORPORATION (US) | 2001-09-20 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030236257-A1 | Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the cogulation cascade | PLG, TFPI, PLAT | ALOX5 495/4885MLYCD 3623/4885NPSR1 3516/4885 |
| US-20020032174-A1 | Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade | TFPI, PLAT, TFPI2 | ALOX5 453/4885MLYCD 3542/4885NPSR1 2115/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.