Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.49 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | MIF | P14174 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2096438 | 0.82 | PRKCI (0.47) | RAB9AKDM4EMAPTALDH1A1PKM | |
| SCHEMBL6242058 | 0.81 | CDK5 (0.57) | RAB9AKDM4EMAPTCYP19A1CDK5 | |
| SCHEMBL6200227 | 0.77 | AR (0.52) | RAB9AKDM4EMAPTALDH1A1PKM | |
| SCHEMBL23204441 | 0.76 | CDK1 (0.53) | RAB9AMAPTCDK5CDK5R1SMN1; SMN2 | |
| SCHEMBL1741719 | 0.76 | CYP19A1 (0.79) | RAB9AKDM4EMAPTALDH1A1PKM | |
| SCHEMBL8801090 | 0.72 | PRKCI (0.46) | RAB9AKDM4EMAPTALDH1A1KDM4C | |
| SCHEMBL17014755 | 0.71 | RAB9A (0.66) | RAB9AKDM4EMAPTALDH1A1PKM | |
| SCHEMBL17873568 | 0.71 | AR (0.54) | RAB9AKDM4EMAPTALDH1A1MAPK1 | |
| SCHEMBL21834624 | 0.70 | HTR3A (0.39) | RAB9AKDM4EMAPTALDH1A1CDK5 | |
| SCHEMBL11017741 | 0.70 | MEN1 (0.74) | RAB9AKDM4EMAPTALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575947-A1 | 2-OXOPYRIDIN-3-YL THIA(DI)AZOLE DERIVATIVES FOR USE IN THE TREATMENT OF CELL PROLIFERATION AND APOPTOSIS RELATED DISEASES | Amgen Inc. (US) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004060890-A1 | 2-OXOPYRIDIN-3-YL THIA (DI) AZOLE DERIVATES FOR USE IN THE TREATMENT OF CELL PROLIFERATION AND APOPTOSIS RELATED DISEASES | AMGEN INC. (US) | 2004-07-22 | — | — | WO | disclosed |