SCHEMBL6250145

SCHEMBL6250145

C[Si](C)(C)c1cnc(C=Cc2cnc(NC(=O)Nc3c(Cl)cccc3Cl)s2)o1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCNB2 O95067 2/20 0.47
CCNE2 O96020 2/20 0.47
CDK1 P06493 2/20 0.47
CCNB1 P14635 2/20 0.47
CCNE1 P24864 2/20 0.47
CDK2 P24941 2/20 0.47
CCNB3 Q8WWL7 2/20 0.47
NPSR1 Q6W5P4 1/20 0.44
KMT2A Q03164 3/20 0.39
MEN1 O00255 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
MAPT P10636 1/20 0.39
NFKB1 P19838 1/20 0.39
RAB9A P51151 1/20 0.39
NFKB2 Q00653 1/20 0.39
RELA Q04206 1/20 0.39
CNR1 P21554 1/20 0.39
LCK P06239 7/20 0.37
MAPK14 Q16539 5/20 0.37
MAPK13 O15264 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6250143 1.00 CCNB2 (0.47) CCNB2CCNE2CDK1CCNB1CCNE1
SCHEMBL6246901 0.88 CDK2 (0.47) CCNB2CCNE2CDK1CCNB1CCNE1
SCHEMBL6246897 0.88 CDK2 (0.47) CCNB2CCNE2CDK1CCNB1CCNE1
SCHEMBL6249487 0.81 OGA (0.43) KMT2AMEN1SMN1; SMN2MAPTRAB9A
SCHEMBL6249483 0.81 OGA (0.43) KMT2AMEN1SMN1; SMN2MAPTRAB9A
SCHEMBL6249236 0.81 KMT2A (0.43) CCNB2CCNE2CDK1CCNB1CCNE1
SCHEMBL6249237 0.81 KMT2A (0.43) CCNB2CCNE2CDK1CCNB1CCNE1
SCHEMBL6248651 0.80 RAB9A (0.46) CCNE1CDK2KMT2AMEN1SMN1; SMN2
SCHEMBL6248648 0.80 RAB9A (0.46) CCNE1CDK2KMT2AMEN1SMN1; SMN2
SCHEMBL6249800 0.80 OGA (0.41) CCNB2CCNE2CDK1CCNB1CCNE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005035541-A1 SILICON COMPOUNDS AND THEIR USE AMEDIS PHARMACEUTICALS LTD. (GB) 2005-04-21 WO disclosed