Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 1/20 | 0.44 |
| ▸ | SKP1 | P63208 | 1/20 | 0.44 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 13/20 | 0.42 |
| ▸ | THRB | P10828 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | ACACA | Q13085 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625132 | 0.88 | CKS1B (0.42) | CKS1BSKP1SKP2MAPTTHRB | |
| SCHEMBL625187 | 0.88 | PIK3CA (0.47) | CKS1BSKP1SKP2SIRT2SIRT1 | |
| SCHEMBL624991 | 0.85 | SYK (0.45) | CKS1BSKP1SKP2PIK3CAMAP3K12 | |
| SCHEMBL626169 | 0.84 | MAP3K12 (0.41) | MAPTTHRBGAAPIK3CALMNA | |
| SCHEMBL624412 | 0.83 | MAP3K12 (0.45) | MAPTPIK3CAMAP3K12 | |
| SCHEMBL626106 | 0.82 | THRB (0.49) | MAPTTHRBGAAPIK3CA | |
| SCHEMBL625422 | 0.82 | PIK3CA (0.42) | CKS1BSKP1SKP2MAPTTHRB | |
| SCHEMBL625621 | 0.81 | MAP3K12 (0.46) | MAPTPIK3CAMAP3K12 | |
| SCHEMBL627373 | 0.80 | MAP3K12 (0.46) | MAPTTHRBPIK3CAMAP3K12 | |
| SCHEMBL626464 | 0.80 | MAPT (0.47) | MAPTTHRBGAAPIK3CALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |