Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.48 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | F2RL3 | Q96RI0 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | SCN4A | P35499 | 1/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625248 | 0.85 | PIM2 (0.51) | PIM2PIM1PIM3 | |
| SCHEMBL623949 | 0.84 | PIM1 (0.47) | PIM2THRBF2RL3MAPTXDH | |
| SCHEMBL624740 | 0.83 | PIM1 (0.48) | PIM2THRBF2RL3MAPTXDH | |
| SCHEMBL623207 | 0.81 | PIM1 (0.48) | PIM2THRBF2RL3MAPTXDH | |
| SCHEMBL625255 | 0.80 | PIM3 (0.48) | PIM2THRBF2RL3MAPTXDH | |
| SCHEMBL624450 | 0.78 | PIM1 (0.54) | PIM2THRBMAPTDGAT2PIM1 | |
| SCHEMBL625512 | 0.76 | THRB (0.44) | THRBF2RL3MAPTRXFP1PIM1 | |
| SCHEMBL623867 | 0.76 | PIM1 (0.44) | THRBF2RL3MAPTXDHRXFP1 | |
| SCHEMBL625777 | 0.76 | MAPT (0.56) | THRBMAPTDGAT2 | |
| SCHEMBL624528 | 0.75 | CYP3A4 (0.41) | THRBMAPTHCRTR1HCRTR2RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |