Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 13/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | F2RL3 | Q96RI0 | 2/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL623996 | 0.95 | THRB (0.42) | THRBMAPTRXFP1F2RL3CYP11B2 | |
| SCHEMBL624528 | 0.92 | CYP3A4 (0.41) | THRBMAPTRXFP1CYP11B2SCD5 | |
| SCHEMBL625496 | 0.86 | PIM1 (0.39) | THRBMAPTF2RL3SCD5PIM1 | |
| SCHEMBL625742 | 0.85 | THRB (0.43) | THRBMAPTRXFP1F2RL3PIM1 | |
| SCHEMBL625511 | 0.85 | PIM1 (0.45) | PIM1 | |
| SCHEMBL623949 | 0.84 | PIM1 (0.47) | THRBMAPTRXFP1F2RL3PIM1 | |
| SCHEMBL624454 | 0.82 | PIM1 (0.45) | F2RL3PIM1 | |
| SCHEMBL625255 | 0.82 | PIM3 (0.48) | THRBMAPTRXFP1F2RL3PIM1 | |
| SCHEMBL624740 | 0.81 | PIM1 (0.48) | THRBMAPTRXFP1F2RL3PIM1 | |
| SCHEMBL623995 | 0.80 | PIM1 (0.44) | CYP11B2PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |