SCHEMBL6252913

SCHEMBL6252913

CC[Si]1(CC)C(c2ccccc2C)=C(c2ccccc2C)C(c2ccccc2C)=C1c1ccccc1C

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 4/20 0.35
SMN1; SMN2 Q16637 4/20 0.35
NPC1 O15118 3/20 0.35
CASP3 P42574 1/20 0.35
SENP8 Q96LD8 1/20 0.35
SENP7 Q9BQF6 1/20 0.35
SENP6 Q9GZR1 1/20 0.35
TSHR P16473 3/20 0.35
ACHE P22303 1/20 0.35
HEXA P06865 1/20 0.33
HEXB P07686 1/20 0.33
HTR7 P34969 2/20 0.32
GAA P10253 2/20 0.32
IDO1 P14902 1/20 0.32
METAP2 P50579 1/20 0.32
NPY5R Q15761 1/20 0.31
RORC P51449 1/20 0.31
HPGD P15428 3/20 0.31
NISCH Q9Y2I1 1/20 0.31
ALDH1A1 P00352 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6253846 0.87 ALDH1A1 (0.39) RAB9ASMN1; SMN2NPC1CASP3SENP8
SCHEMBL6254495 0.82 NPC1 (0.34) RAB9ASMN1; SMN2NPC1CASP3SENP8
SCHEMBL6252883 0.77 TSHR (0.39) RAB9ASMN1; SMN2NPC1CASP3SENP8
SCHEMBL6256128 0.74 CYP2D6 (0.36) RAB9ASMN1; SMN2NPC1ALDH1A1MAPT
SCHEMBL6257927 0.72 NPC1 (0.35) RAB9ASMN1; SMN2NPC1CASP3SENP8
SCHEMBL6253609 0.72 ALDH1A1 (0.35) RAB9ASMN1; SMN2NPC1CASP3SENP8
SCHEMBL6254378 0.71 ALDH1A1 (0.38) RAB9ASMN1; SMN2NPC1CASP3SENP8
SCHEMBL6257017 0.67 NPC1 (0.32) RAB9ASMN1; SMN2NPC1CASP3SENP8
SCHEMBL197690 0.67 ACHE (0.64) RAB9ASMN1; SMN2NPC1CASP3SENP8
SCHEMBL30354037 0.67 ACHE (0.64) RAB9ASMN1; SMN2NPC1CASP3SENP8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1143538-B1 Organic electroluminescent element containing a silacyclopentadiene derivative CHISSO CORP (JP) 2005-09-14 EP disclosed
EP-0754691-B1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORP (JP) 2003-11-19 EP disclosed
EP-1143538-A1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative Chisso Corporation (JP) 2001-10-10 EP disclosed
US-6051319-A Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 2000-04-18 US disclosed
US-5986121-A Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 1999-11-16 US disclosed
EP-0754691-A2 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 1997-01-22 EP disclosed