SCHEMBL6252883

SCHEMBL6252883

Cc1ccccc1C1=C(c2ccccc2C)[Si](C)(C)C(c2ccccc2C)=C1c1ccccc1C

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.39
ACHE P22303 2/20 0.39
ALDH1A1 P00352 4/20 0.39
NPSR1 Q6W5P4 2/20 0.39
KDM4E B2RXH2 1/20 0.39
PRNP P04156 1/20 0.39
PPARG P37231 1/20 0.39
MAPK10 P53779 1/20 0.39
NCOA2 Q15596 1/20 0.39
NCOA1 Q15788 1/20 0.39
RXFP1 Q9HBX9 1/20 0.39
NPC1 O15118 3/20 0.39
RAB9A P51151 3/20 0.39
SMN1; SMN2 Q16637 3/20 0.39
CASP3 P42574 1/20 0.39
SENP8 Q96LD8 1/20 0.39
SENP7 Q9BQF6 1/20 0.39
SENP6 Q9GZR1 1/20 0.39
GAA P10253 1/20 0.34
IDO1 P14902 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6257692 0.85 ALDH1A1 (0.42) TSHRACHEALDH1A1NPSR1KDM4E
SCHEMBL6254495 0.79 NPC1 (0.34) TSHRACHEALDH1A1NPC1RAB9A
SCHEMBL6252863 0.78 TSHR (0.42) TSHRACHEALDH1A1NPSR1NPC1
SCHEMBL6252913 0.77 RAB9A (0.35) TSHRACHEALDH1A1NPC1RAB9A
SCHEMBL6257927 0.77 NPC1 (0.35) TSHRACHEALDH1A1NPC1RAB9A
SCHEMBL6257017 0.71 NPC1 (0.32) TSHRACHEALDH1A1NPC1RAB9A
SCHEMBL30354037 0.71 ACHE (0.64) TSHRACHEALDH1A1NPC1RAB9A
SCHEMBL30169568 0.71 ACHE (0.64) TSHRACHEALDH1A1NPC1RAB9A
SCHEMBL197690 0.71 ACHE (0.64) TSHRACHEALDH1A1NPC1RAB9A
SCHEMBL6256989 0.69 ALDH1A1 (0.39) TSHRALDH1A1NPSR1KDM4ENPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1143538-B1 Organic electroluminescent element containing a silacyclopentadiene derivative CHISSO CORP (JP) 2005-09-14 EP disclosed
EP-0754691-B1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORP (JP) 2003-11-19 EP disclosed
EP-1143538-A1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative Chisso Corporation (JP) 2001-10-10 EP disclosed
US-6051319-A Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 2000-04-18 US disclosed
US-5986121-A Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 1999-11-16 US disclosed
EP-0754691-A2 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 1997-01-22 EP disclosed