Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
| ▸ | CETP | P11597 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | PKLR | P30613 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625892 | 0.84 | TRPV3 (0.41) | TRPV3HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL624452 | 0.84 | NR1I2 (0.59) | NR1I2TRPV3HDAC6HDAC3HDAC1 | |
| SCHEMBL626252 | 0.82 | TRPV3 (0.44) | TRPV3HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL625907 | 0.81 | NR1I2 (0.46) | NR1I2TRPV3HDAC6HDAC3HDAC1 | |
| SCHEMBL14893798 | 0.75 | NR1I2 (0.57) | NR1I2TRPV3HDAC6HDAC3HDAC1 | |
| SCHEMBL14894470 | 0.75 | NR1I2 (0.57) | NR1I2TRPV3HDAC6HDAC3HDAC1 | |
| SCHEMBL14893800 | 0.75 | NR1I2 (0.57) | NR1I2TRPV3HDAC6HDAC3HDAC1 | |
| SCHEMBL624777 | 0.75 | NR1I2 (0.43) | NR1I2TRPV3HDAC6HDAC3HDAC1 | |
| SCHEMBL625410 | 0.75 | TRPV3 (0.68) | TRPV3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL625906 | 0.74 | NR1I2 (0.46) | NR1I2TRPV3HDAC6HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603490-A1 | NOVEL TRPV3 MODULATORS | AbbVie Inc. (US) | 2013-06-19 | — | — | EP | disclosed |
| WO-2012019315-A1 | NOVEL TRPV3 MODULATORS | ABBOTT LABORATORIES (US) | 2012-02-16 | — | — | WO | disclosed |