Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625892 | 0.85 | TRPV3 (0.41) | TRPV3OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL625303 | 0.82 | NR1I2 (0.43) | TRPV3OPRL1HDAC3HDAC1HDAC2 | |
| SCHEMBL625908 | 0.81 | TRPV3 (0.65) | TRPV3OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL625410 | 0.81 | TRPV3 (0.68) | TRPV3CYP2D6SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL27925739 | 0.79 | SLC6A4 (0.41) | TRPV3OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL625715 | 0.78 | TRPV3 (0.46) | TRPV3OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL624615 | 0.71 | TRPV3 (0.46) | TRPV3OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL625714 | 0.71 | SLC6A4 (0.43) | TRPV3OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL626324 | 0.71 | TRPV3 (0.52) | TRPV3OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL27925738 | 0.71 | SLC6A4 (0.41) | TRPV3OPRM1OPRD1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603490-A1 | NOVEL TRPV3 MODULATORS | AbbVie Inc. (US) | 2013-06-19 | — | — | EP | disclosed |
| WO-2012019315-A1 | NOVEL TRPV3 MODULATORS | ABBOTT LABORATORIES (US) | 2012-02-16 | — | — | WO | disclosed |