Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | VNN1 | O95497 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL626252 | 0.85 | TRPV3 (0.44) | TRPV3SLC6A4SLC6A3SLC6A2OPRM1 | |
| SCHEMBL625303 | 0.84 | NR1I2 (0.43) | TRPV3SLC6A4SLC6A3SLC6A2OPRL1 | |
| SCHEMBL625314 | 0.82 | TRPV3 (0.61) | TRPV3SLC6A4VNN1MAPTPOLB | |
| SCHEMBL625410 | 0.78 | TRPV3 (0.68) | TRPV3SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL14893478 | 0.74 | TRPV3 (0.53) | TRPV3VNN1MAPTPOLBNPSR1 | |
| SCHEMBL14894541 | 0.74 | TRPV3 (0.53) | TRPV3VNN1MAPTPOLBNPSR1 | |
| SCHEMBL14893863 | 0.74 | TRPV3 (0.53) | TRPV3VNN1MAPTPOLBNPSR1 | |
| SCHEMBL627064 | 0.73 | SLC6A4 (0.49) | TRPV3SLC6A4MAPTPOLBNPSR1 | |
| SCHEMBL624676 | 0.72 | TRPV3 (0.64) | TRPV3MAPTPOLBNPSR1KDM4E | |
| SCHEMBL14894318 | 0.72 | NR1I2 (0.61) | TRPV3SLC6A4MAPTPOLBNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603490-A1 | NOVEL TRPV3 MODULATORS | AbbVie Inc. (US) | 2013-06-19 | — | — | EP | disclosed |
| WO-2012019315-A1 | NOVEL TRPV3 MODULATORS | ABBOTT LABORATORIES (US) | 2012-02-16 | — | — | WO | disclosed |