Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.36 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | ALPI | P09923 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625347 | 1.00 | KMT2A (0.45) | KMT2AMAOAMAOBPIM1PIM2 | |
| SCHEMBL28371952 | 1.00 | KMT2A (0.45) | KMT2AMAOAMAOBPIM1PIM2 | |
| SCHEMBL28885464 | 0.83 | PIM1 (0.44) | MAOAMAOBPIM1PIM2PARP10 | |
| SCHEMBL28927253 | 0.83 | PARP10 (0.33) | PARP10PARP11PARP1 | |
| SCHEMBL28885466 | 0.83 | PIM1 (0.44) | MAOAMAOBPIM1PIM2PARP10 | |
| SCHEMBL625684 | 0.83 | CYP2C9 (0.47) | KMT2AMAOAMAOBMEN1TDP1 | |
| SCHEMBL625683 | 0.83 | CYP2C9 (0.47) | KMT2AMAOAMAOBMEN1TDP1 | |
| SCHEMBL624212 | 0.83 | HSD11B1 (0.47) | KMT2AMAOAMAOBPIM1PIM2 | |
| SCHEMBL624211 | 0.83 | HSD11B1 (0.47) | KMT2AMAOAMAOBPIM1PIM2 | |
| SCHEMBL28375460 | 0.83 | HSD11B1 (0.47) | KMT2AMAOAMAOBPIM1PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110878095-B | Curcumin bifunctional molecule and preparation method and application thereof | 中山大学 | 2023-01-24 | — | — | CN | disclosed |
| CN-115232068-A | Compound and preparation method and application thereof | 北京中医药大学 | 2022-10-25 | — | — | CN | disclosed |
| CN-110878095-A | Curcumin bifunctional molecule and preparation method and application thereof | 中山大学 | 2020-03-13 | — | — | CN | disclosed |
| WO-2012021692-A1 | CURCUMIN ANALOGS AND METHODS OF USE THEREOF | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2012-02-16 | — | — | WO | disclosed |