Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.51 |
| ▸ | MMP2 | P08253 | 5/20 | 0.43 |
| ▸ | MMP12 | P39900 | 3/20 | 0.43 |
| ▸ | MMP8 | P22894 | 2/20 | 0.43 |
| ▸ | MMP9 | P14780 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | ESRRG | P62508 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4839942 | 0.88 | CA2 (0.45) | MMEL1MMP2MMP8MMP9MEN1 | |
| SCHEMBL4840798 | 0.84 | MMP2 (0.45) | MMP2MMP8MMP9ESRRGCA2 | |
| SCHEMBL6252523 | 0.84 | MMEL1 (0.68) | MMEL1MMP2MMP12MMP8MMP9 | |
| SCHEMBL4840357 | 0.82 | MMEL1 (0.60) | MMEL1MMP2MMP8MMP9MMP14 | |
| SCHEMBL4841261 | 0.82 | ABCB1 (0.46) | MMP2MMP12MMP8MMP9ESRRG | |
| SCHEMBL4840314 | 0.82 | CA2 (0.40) | MMP2MMP8MMP9ESRRGCA1 | |
| SCHEMBL4831392 | 0.80 | CA2 (0.43) | MMEL1MMP2MMP12MMP8MMP9 | |
| SCHEMBL4835699 | 0.80 | SMN1; SMN2 (0.43) | MEN1KMT2ACA1CA2CA9 | |
| SCHEMBL4838858 | 0.78 | CA2 (0.39) | ESRRGCA2CA9MMP3 | |
| SCHEMBL4831283 | 0.78 | CA2 (0.49) | MMP8MMP9MEN1KMT2ACA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572645-A2 | DERIVATIVES OF SUCCINIC AND GLUTARIC ACIDS AND ANALOGS THEREOF USEFUL AS INHIBITORS OF PHEX | Enobia Pharma Inc. (CA) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004050620-A2 | DERIVATIVES OF SUCCINIC AND GLUTARIC ACIDS AND ANALOGS THEREOF USEFUL AS INHIBITORS OF PHEX | ENOBIA PHARMA (CA) | 2004-06-17 | — | — | WO | disclosed |