Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | CPA1 | P15085 | 2/20 | 0.45 |
| ▸ | CPB1 | P15086 | 1/20 | 0.45 |
| ▸ | CPA3 | P15088 | 1/20 | 0.45 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 2/20 | 0.37 |
| ▸ | FDFT1 | P37268 | 2/20 | 0.37 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 3/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.36 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4837207 | 0.84 | CYP3A4 (0.44) | CYP3A4CYP2C9KCNH2TSHRSLC15A1 | |
| SCHEMBL14193602 | 0.83 | CYP3A4 (0.46) | CYP3A4CYP2C9KCNH2TSHRLTA4H | |
| SCHEMBL5318616 | 0.79 | KCNH2 (0.52) | CYP3A4CYP2C9KCNH2TSHRKDM4E | |
| SCHEMBL6253965 | 0.78 | MMEL1 (0.51) | — | |
| SCHEMBL14564239 | 0.76 | CYP3A4 (0.64) | CYP3A4CYP2C9KCNH2KDM4EKIF11 | |
| SCHEMBL19474711 | 0.76 | CYP3A4 (0.59) | CYP3A4CYP2C9KCNH2LTA4HKIF11 | |
| SCHEMBL4837398 | 0.74 | KMT2A (0.44) | CYP3A4CYP2C9KCNH2KIF11 | |
| SCHEMBL4835594 | 0.73 | CYP3A4 (0.47) | CYP3A4CYP2C9KCNH2TSHRKDM4E | |
| SCHEMBL15797920 | 0.73 | CYP3A4 (0.76) | CYP3A4CYP2C9KCNH2TSHRALDH1A1 | |
| Tricarballylic Acid SCHEMBL29098246 | 0.69 | CPA1 (0.60) | CPA1CPB1CPA3CPB2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572645-A2 | DERIVATIVES OF SUCCINIC AND GLUTARIC ACIDS AND ANALOGS THEREOF USEFUL AS INHIBITORS OF PHEX | Enobia Pharma Inc. (CA) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004050620-A2 | DERIVATIVES OF SUCCINIC AND GLUTARIC ACIDS AND ANALOGS THEREOF USEFUL AS INHIBITORS OF PHEX | ENOBIA PHARMA (CA) | 2004-06-17 | — | — | WO | disclosed |