Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | CCR6 | P51684 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19007841 | 0.85 | NPC1 (0.47) | SMN1; SMN2LMNACA12CA1CA2 | |
| SCHEMBL13188795 | 0.83 | NPC1 (0.45) | SMN1; SMN2LMNACA12CA1CA2 | |
| SCHEMBL9228433 | 0.83 | HTT (0.45) | SMN1; SMN2LMNACA12CA1CA2 | |
| SCHEMBL7355378 | 0.82 | HTT (0.50) | SMN1; SMN2LMNACA12CA1CA2 | |
| SCHEMBL989681 | 0.82 | CCR6 (0.48) | SMN1; SMN2LMNACA12CA1CA2 | |
| SCHEMBL25298888 | 0.81 | NPC1 (0.46) | SMN1; SMN2LMNACA12CA1CA2 | |
| SCHEMBL16667746 | 0.81 | SMN1; SMN2 (0.42) | SMN1; SMN2LMNACA12CA1CA2 | |
| SCHEMBL13189129 | 0.81 | NPC1 (0.43) | SMN1; SMN2LMNACA12CA1CA2 | |
| SCHEMBL6252907 | 0.80 | ALDH1A1 (0.53) | SMN1; SMN2LMNACA12CA1CA2 | |
| SCHEMBL2321117 | 0.80 | LMNA (0.56) | SMN1; SMN2LMNACA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575912-A1 | VARIOUSLY SUBSTITUTED DERIVATIVES OF GUANIDINE, AND THEIR USE AS MEDICINES WITH ANTI-DIABETES AND/OR ANTI-OBESITY ACTIVITY | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. (IT) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004054967-A1 | VARIOUSLY SUBSTITUTED DERIVATIVES OF GUANIDINE, AND THEIR USE AS MEDICINES WITH ANTI-DIABETES AND/OR ANTI-OBESITY ACTIVITY | SIGMA TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2004-07-01 | — | — | WO | disclosed |