SCHEMBL6256347

SCHEMBL6256347

Cc1cccc(C2=C(c3cccc(C)c3)[Si](C)(C)C(c3cccc(C)c3)=C2c2cccc(C)c2)c1

nearest known ligand 0.44

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ACHE P22303 3/20 0.44
RAB9A P51151 2/20 0.40
NPC1 O15118 1/20 0.39
HPGD P15428 1/20 0.39
TSHR P16473 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
IDO1 P14902 1/20 0.38
METAP2 P50579 1/20 0.38
ALDH1A1 P00352 4/20 0.37
KMT2A Q03164 2/20 0.37
NISCH Q9Y2I1 1/20 0.37
CHRNB4 P30926 1/20 0.37
CHRNA3 P32297 1/20 0.37
MEN1 O00255 1/20 0.37
MAPK1 P28482 1/20 0.37
GALR1 P47211 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.36
AKR1C2 P52895 1/20 0.36
AKR1C1 Q04828 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6253918 0.92 RAB9A (0.44) ACHERAB9ANPC1HPGDTSHR
SCHEMBL6254825 0.92 RAB9A (0.44) ACHERAB9ANPC1HPGDTSHR
SCHEMBL6256101 0.90 ACHE (0.39) ACHERAB9ANPC1HPGDTSHR
SCHEMBL6255270 0.89 ACHE (0.52) ACHERAB9ANPC1HPGDSMN1; SMN2
SCHEMBL6257971 0.87 CYP2A6 (0.44) RAB9ANPC1HPGDTSHRSMN1; SMN2
SCHEMBL6255417 0.87 ACHE (0.55) ACHERAB9ANPC1HPGDTSHR
SCHEMBL6252548 0.87 RPS6KA3 (0.39) ACHERAB9ANPC1HPGDSMN1; SMN2
SCHEMBL6253418 0.87 BCL2 (0.39) ACHERAB9ANPC1SMN1; SMN2IDO1
SCHEMBL6257061 0.86 SMN1; SMN2 (0.47) ACHERAB9ANPC1HPGDSMN1; SMN2
SCHEMBL6259233 0.85 PTPN5 (0.46) RAB9AHPGDIDO1ALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1143538-B1 Organic electroluminescent element containing a silacyclopentadiene derivative CHISSO CORP (JP) 2005-09-14 EP disclosed
EP-0754691-B1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORP (JP) 2003-11-19 EP disclosed
EP-1143538-A1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative Chisso Corporation (JP) 2001-10-10 EP disclosed
US-6051319-A Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 2000-04-18 US disclosed
US-5986121-A Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 1999-11-16 US disclosed
EP-0754691-A2 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 1997-01-22 EP disclosed