SCHEMBL6259233

SCHEMBL6259233

Cc1cccc(C2=C(c3cccc(C(F)(F)F)c3)[Si](C)(C)C(c3cccc(C(F)(F)F)c3)=C2c2cccc(C)c2)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTPN5 P54829 1/20 0.46
KDM4E B2RXH2 2/20 0.43
HSD17B10 Q99714 2/20 0.43
ALDH1A1 P00352 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
GABRA1 P14867 1/20 0.40
HPGD P15428 1/20 0.40
GABRG2 P18507 1/20 0.40
GABRB3 P28472 1/20 0.40
GABRA5 P31644 1/20 0.40
GABRA3 P34903 1/20 0.40
GABRA2 P47869 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
IKBKB O14920 1/20 0.40
BRD4 O60885 1/20 0.40
MEN1 O00255 1/20 0.39
HTT P42858 1/20 0.39
RAB9A P51151 1/20 0.39
KMT2A Q03164 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6255418 0.88 KIF11 (0.42) PTPN5KDM4EHPGDTDP1RAB9A
SCHEMBL6259257 0.86 SCN2A (0.43) PTPN5KDM4EHSD17B10ALDH1A1CYP1A2
SCHEMBL6256347 0.85 ACHE (0.44) ALDH1A1HPGDMEN1RAB9AKMT2A
SCHEMBL2662898 0.82 PTPN5 (0.62) PTPN5KDM4EHSD17B10ALDH1A1IKBKB
SCHEMBL20022104 0.80 PTPN5 (0.60) PTPN5KDM4EHSD17B10ALDH1A1IKBKB
SCHEMBL20022132 0.80 PTPN5 (0.60) PTPN5KDM4EHSD17B10ALDH1A1IKBKB
SCHEMBL6255270 0.80 ACHE (0.52) KDM4EHSD17B10ALDH1A1CYP1A2HPGD
SCHEMBL20022097 0.79 PTPN5 (0.58) PTPN5KDM4EHSD17B10ALDH1A1IKBKB
SCHEMBL6253918 0.79 RAB9A (0.44) ALDH1A1HPGDRAB9AKMT2A
SCHEMBL6254825 0.79 RAB9A (0.44) ALDH1A1HPGDRAB9AKMT2AIDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1143538-B1 Organic electroluminescent element containing a silacyclopentadiene derivative CHISSO CORP (JP) 2005-09-14 EP disclosed
EP-0754691-B1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORP (JP) 2003-11-19 EP disclosed
EP-1143538-A1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative Chisso Corporation (JP) 2001-10-10 EP disclosed
US-6051319-A Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 2000-04-18 US disclosed
US-5986121-A Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 1999-11-16 US disclosed
EP-0754691-A2 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 1997-01-22 EP disclosed