Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 3/20 | 0.54 |
| ▸ | CES1 | P23141 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.48 |
| ▸ | NAAA | Q02083 | 1/20 | 0.45 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14071609 | 0.84 | NPC1 (0.50) | CES2CES1NPC1JAK2RAB9A | |
| SCHEMBL10969535 | 0.82 | TP53 (0.53) | CES2CES1NPC1JAK2RAB9A | |
| SCHEMBL9666974 | 0.82 | NPC1 (0.48) | CES2CES1NPC1JAK2RAB9A | |
| SCHEMBL28704462 | 0.81 | SOAT2 (0.58) | LMNAMAPTTDP1EPHX2 | |
| SCHEMBL11902609 | 0.81 | KMT2A (0.47) | CES2CES1NPC1JAK2RAB9A | |
| SCHEMBL6958752 | 0.80 | ALDH1A1 (0.47) | CES2CES1RAB9ATP53L3MBTL1 | |
| SCHEMBL3125344 | 0.80 | CES2 (0.55) | CES2CES1NPC1JAK2RAB9A | |
| SCHEMBL7643097 | 0.79 | NPC1 (0.54) | CES2CES1NPC1JAK2RAB9A | |
| SCHEMBL18240156 | 0.79 | NPC1 (0.54) | CES2CES1NPC1JAK2RAB9A | |
| SCHEMBL18240146 | 0.79 | NPC1 (0.54) | CES2CES1NPC1JAK2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1524262-A1 | Inhibitors of histone deacetylase | Methylgene, Inc. (CA) | 2005-04-20 | — | — | EP | disclosed |