Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MLYCD | O95822 | 1/20 | 0.36 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | CTSG | P08311 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6257488 | 1.00 | SMN1; SMN2 (0.38) | SMN1; SMN2ALDH1A1TP53LMNATSHR | |
| SCHEMBL9407522 | 0.85 | SMN1; SMN2 (0.42) | SMN1; SMN2ALDH1A1TP53LMNATSHR | |
| SCHEMBL9382586 | 0.84 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1TP53LMNATSHR | |
| SCHEMBL642839 | 0.84 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1TP53LMNATSHR | |
| SCHEMBL8724217 | 0.81 | NR1H2 (0.39) | SMN1; SMN2ALDH1A1TP53LMNATSHR | |
| SCHEMBL27751076 | 0.80 | SMN1; SMN2 (0.39) | SMN1; SMN2ALDH1A1TP53LMNATSHR | |
| SCHEMBL31324787 | 0.79 | SMN1; SMN2 (0.38) | SMN1; SMN2ALDH1A1TP53LMNATSHR | |
| SCHEMBL8539792 | 0.78 | SMN1; SMN2 (0.40) | SMN1; SMN2ALDH1A1TP53LMNATSHR | |
| SCHEMBL3288030 | 0.78 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1TP53LMNATSHR | |
| SCHEMBL1134230 | 0.78 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1TP53LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1299103-B1 | 4,5-DIHYDRO-THIAZO-2-YLAMINE DERIVATIVES AND THEIR USE AS NO-SYNTHASE INHIBITORS | AVENTIS PHARMA SA (FR) | 2005-09-28 | — | — | EP | disclosed |
| CN-1441673-A | 4,5-dihydro-thiazo-2-ylamine derivatives and their use as NO-synthase inhibitors | AVENTIS PHARMA SA (FR) | 2003-09-10 | — | — | CN | disclosed |
| EP-1299103-A1 | 4,5-DIHYDRO-THIAZO-2-YLAMINE DERIVATIVES AND THEIR USE AS NO-SYNTHASE INHIBITORS | Aventis Pharma S.A. (FR) | 2003-04-09 | — | — | EP | disclosed |
| US-6420566-B2 | NITRIC OXIDE SYNTHASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2002-07-16 | — | — | US | disclosed |
| US-20020019427-A1 | Pharmaceutical compositions containing a 4, 5-dihydro-1, 3-thiazol-2-ylamine derivative, novel derivatives and preparation thereof | AVENTIS PHARMA S.A. (FR) | 2002-02-14 | — | — | US | disclosed |
| WO-2001093867-A1 | 4,5-DIHYDRO-THIAZO-2-YLAMINE DERIVATIVES AND THEIR USE AS NO-SYNTHASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2001-12-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020019427-A1 | Pharmaceutical compositions containing a 4, 5-dihydro-1, 3-thiazol-2-ylamine derivative, novel derivatives and preparation thereof | ALK, QDPR, CYP3A7 | SMN1; SMN2 2312/4885ALDH1A1 22/4885TP53 4023/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.