SCHEMBL6257644

SCHEMBL6257644

CC[Si]1(CC)C(c2ccccc2F)=C(c2ccccc2)C(c2ccccc2)=C1c1ccccc1F

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 2/20 0.36
RAB9A P51151 2/20 0.36
L3MBTL1 Q9Y468 2/20 0.36
MEN1 O00255 1/20 0.36
PKM P14618 1/20 0.36
NFKB1 P19838 1/20 0.36
MAPK1 P28482 1/20 0.36
NFKB2 Q00653 1/20 0.36
KMT2A Q03164 1/20 0.36
RELA Q04206 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
DPP4 P27487 1/20 0.33
ALDH1A1 P00352 4/20 0.33
KDM4E B2RXH2 2/20 0.33
LMNA P02545 1/20 0.33
DRD2 P14416 1/20 0.32
DRD4 P21917 1/20 0.32
DRD3 P35462 1/20 0.32
MAPT P10636 4/20 0.32
GRIA4 P48058 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6259847 0.85 NPC1 (0.35) NPC1RAB9AL3MBTL1MEN1PKM
SCHEMBL6253846 0.81 ALDH1A1 (0.39) NPC1RAB9AL3MBTL1MEN1KMT2A
SCHEMBL6254578 0.80 MEN1 (0.39) NPC1RAB9AL3MBTL1MEN1PKM
SCHEMBL6257757 0.79 L3MBTL1 (0.36) NPC1RAB9AL3MBTL1MEN1PKM
SCHEMBL6253373 0.79 ALDH1A1 (0.35) L3MBTL1KMT2ASMN1; SMN2ALDH1A1MAPT
SCHEMBL6258560 0.79 HSD11B1 (0.43) L3MBTL1DPP4ALDH1A1
SCHEMBL6253838 0.78
SCHEMBL6254629 0.77 NR1H2 (0.31)
SCHEMBL6256567 0.77 PTGS1 (0.40) L3MBTL1MEN1MAPK1KMT2ADPP4
SCHEMBL6254632 0.77 ALDH1A1 (0.43) NPC1RAB9AL3MBTL1SMN1; SMN2DPP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1143538-B1 Organic electroluminescent element containing a silacyclopentadiene derivative CHISSO CORP (JP) 2005-09-14 EP disclosed
EP-0754691-B1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORP (JP) 2003-11-19 EP disclosed
EP-1143538-A1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative Chisso Corporation (JP) 2001-10-10 EP disclosed
US-6051319-A Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 2000-04-18 US disclosed
US-5986121-A Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 1999-11-16 US disclosed
EP-0754691-A2 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 1997-01-22 EP disclosed