SCHEMBL6257663

SCHEMBL6257663

CC(C)(C)[Si]1(c2ccccc2)C(c2ccccc2F)=C(c2ccccc2)C(c2ccccc2)=C1c1ccccc1F

nearest known ligand 0.35

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.35
NPC1 O15118 2/20 0.33
PKM P14618 2/20 0.33
RAB9A P51151 2/20 0.33
MEN1 O00255 1/20 0.33
NFKB1 P19838 1/20 0.33
MAPK1 P28482 1/20 0.33
NFKB2 Q00653 1/20 0.33
KMT2A Q03164 1/20 0.33
RELA Q04206 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
ADORA2B P29275 1/20 0.30
ADORA1 P30542 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6254810 0.83 ALDH1A1 (0.36) MAPTNPC1RAB9AMEN1KMT2A
SCHEMBL6254637 0.82 HSD11B1 (0.41) L3MBTL1
SCHEMBL6255419 0.81 PDE4B (0.31)
SCHEMBL6252278 0.80
SCHEMBL6253057 0.79
SCHEMBL6252814 0.79 PTGS1 (0.37) ADORA1
SCHEMBL6254591 0.79 ALDH1A1 (0.39) MAPTMEN1NFKB1MAPK1NFKB2
SCHEMBL6257264 0.79 ALDH1A1 (0.40) MAPTNPC1RAB9ASMN1; SMN2L3MBTL1
SCHEMBL6252766 0.79 HSD17B1 (0.34) NPC1RAB9A
SCHEMBL6254382 0.78 MEN1 (0.38) MAPTNPC1PKMRAB9AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1143538-B1 Organic electroluminescent element containing a silacyclopentadiene derivative CHISSO CORP (JP) 2005-09-14 EP disclosed
EP-0754691-B1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORP (JP) 2003-11-19 EP disclosed
EP-1143538-A1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative Chisso Corporation (JP) 2001-10-10 EP disclosed
US-6051319-A Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 2000-04-18 US disclosed
US-5986121-A Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 1999-11-16 US disclosed
EP-0754691-A2 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 1997-01-22 EP disclosed