Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.49 |
| ▸ | GBA1 | P04062 | 1/20 | 0.49 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.40 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.40 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.40 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.40 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.40 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.40 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.40 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.40 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7466506 | 0.77 | GPR119 (0.46) | GPR119GBA1KDM1APDE4B | |
| SCHEMBL3805418 | 0.75 | KDM1A (0.53) | GPR119KDM1APDE4APDE4BPDE4C | |
| SCHEMBL3706690 | 0.74 | KDM1A (0.52) | GPR119KDM1APDE4APDE4BPDE4C | |
| SCHEMBL2499402 | 0.74 | IKBKB (0.57) | GPR119GBA1KDM1APDE4APDE4B | |
| SCHEMBL213729 | 0.73 | KDM1A (0.56) | GPR119KDM1APDE4APDE4BPDE4C | |
| SCHEMBL5454387 | 0.72 | GPR119 (0.57) | GPR119KDM1APDE4APDE4BPDE4C | |
| SCHEMBL30659313 | 0.72 | GPR119 (0.53) | GPR119KDM1APDE4APDE4BPDE4C | |
| SCHEMBL3713722 | 0.72 | KDM1A (0.50) | GPR119KDM1APDE4APDE4BPDE4C | |
| SCHEMBL3714938 | 0.72 | KDM1A (0.50) | GPR119KDM1APDE4APDE4BPDE4C | |
| SCHEMBL1632232 | 0.72 | KDM1A (0.50) | GPR119KDM1APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005007099-A2 | PKB INHIBITORS AS ANTI-TUMOR AGENTS | IMCLONE SYSTEMS INCORPORATED (US) | 2005-01-27 | — | — | WO | disclosed |