SCHEMBL6258552

SCHEMBL6258552

Cc1cccc(C2=C(c3cccc(-c4nc5ccccc5s4)c3)[Si](C)(C)C(c3cccc(-c4nc5ccccc5s4)c3)=C2c2cccc(C)c2)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 8/20 0.51
RAB9A P51151 7/20 0.51
SMN1; SMN2 Q16637 7/20 0.51
MAPT P10636 7/20 0.51
NPC1 O15118 5/20 0.51
ALDH1A1 P00352 5/20 0.51
NFKB1 P19838 3/20 0.51
NFKB2 Q00653 3/20 0.51
RELA Q04206 3/20 0.51
MEN1 O00255 3/20 0.51
KMT2A Q03164 3/20 0.51
HSD17B10 Q99714 3/20 0.51
TP53 P04637 2/20 0.51
LMNA P02545 1/20 0.51
POLB P06746 1/20 0.51
TDP1 Q9NUW8 2/20 0.51
GAA P10253 2/20 0.46
APP P05067 3/20 0.45
HPGD P15428 3/20 0.44
L3MBTL1 Q9Y468 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6255933 0.93 RAB9A (0.48) KDM4ERAB9ASMN1; SMN2MAPTNPC1
SCHEMBL6254864 0.91 RAB9A (0.48) KDM4ERAB9ASMN1; SMN2MAPTNPC1
SCHEMBL6256560 0.90 RAB9A (0.56) KDM4ERAB9ASMN1; SMN2MAPTNPC1
SCHEMBL6257841 0.87 KDM4E (0.47) KDM4ERAB9ASMN1; SMN2MAPTNPC1
SCHEMBL16141213 0.86 RAB9A (0.63) KDM4ERAB9ASMN1; SMN2MAPTNPC1
SCHEMBL2139503 0.85 RAB9A (0.67) KDM4ERAB9ASMN1; SMN2MAPTNPC1
SCHEMBL6254523 0.81 SMN1; SMN2 (0.50) KDM4ERAB9ASMN1; SMN2MAPTNPC1
SCHEMBL6254376 0.80 SMN1; SMN2 (0.43) KDM4ERAB9ASMN1; SMN2MAPTNPC1
SCHEMBL6257079 0.79 APP (0.55) KDM4ERAB9ASMN1; SMN2MAPTNPC1
SCHEMBL5461064 0.78 RAB9A (0.77) KDM4ERAB9ASMN1; SMN2MAPTNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1143538-B1 Organic electroluminescent element containing a silacyclopentadiene derivative CHISSO CORP (JP) 2005-09-14 EP disclosed
EP-0754691-B1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORP (JP) 2003-11-19 EP disclosed
EP-1143538-A1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative Chisso Corporation (JP) 2001-10-10 EP disclosed
US-6051319-A Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 2000-04-18 US disclosed
US-5986121-A Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 1999-11-16 US disclosed
EP-0754691-A2 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 1997-01-22 EP disclosed