Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 2/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625860 | 0.79 | GPR119 (0.47) | PIK3CAGPR119RIPK1 | |
| SCHEMBL2121133 | 0.74 | PIK3CA (0.77) | PIK3CAALK | |
| SCHEMBL624921 | 0.74 | PIK3CA (0.49) | PIK3CAGPR119RIPK1 | |
| SCHEMBL625421 | 0.72 | PIK3CA (0.52) | PIK3CAGPR119KITRIPK1 | |
| SCHEMBL624393 | 0.71 | FYN (0.46) | PIK3CA | |
| SCHEMBL625127 | 0.69 | PIK3CA (0.48) | PIK3CARIPK1 | |
| SCHEMBL29029902 | 0.69 | DDB1 (0.45) | GPR119KITALK | |
| SCHEMBL625653 | 0.69 | PIK3CA (0.54) | PIK3CA | |
| SCHEMBL31410416 | 0.68 | KMT2A (0.57) | GPR119KIT | |
| SCHEMBL31410432 | 0.68 | KMT2A (0.57) | GPR119KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |