Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 8/20 | 0.48 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 7/20 | 0.45 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625455 | 0.90 | PIK3CA (0.43) | PIK3CARIPK1FYNHASPIN | |
| SCHEMBL625407 | 0.90 | PIK3CA (0.45) | PIK3CARIPK1FYNHASPIN | |
| SCHEMBL624427 | 0.89 | PIK3CA (0.50) | PIK3CAFYNHASPIN | |
| SCHEMBL624984 | 0.88 | PIK3CA (0.48) | PIK3CARIPK1FYN | |
| SCHEMBL626893 | 0.88 | PIK3CA (0.49) | PIK3CAFYNHASPIN | |
| SCHEMBL626891 | 0.88 | PIK3CA (0.49) | PIK3CAFYNHASPIN | |
| SCHEMBL624920 | 0.86 | PIK3CA (0.46) | PIK3CARIPK1CCNA2CDK2SYK | |
| SCHEMBL625128 | 0.85 | CCNA2 (0.46) | PIK3CARIPK1CCNA2CDK2SYK | |
| SCHEMBL626544 | 0.85 | ACKR3 (0.55) | PIK3CARIPK1FYN | |
| SCHEMBL624921 | 0.84 | PIK3CA (0.49) | PIK3CARIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |