Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.52 |
| ▸ | CYSLTR2 | Q9NS75 | 4/20 | 0.47 |
| ▸ | CYSLTR1 | Q9Y271 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.42 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.41 |
| ▸ | CXCL8 | P10145 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8086649 | 0.84 | TSHR (0.53) | AKR1B1CYSLTR2CYSLTR1TDP1PTGS2 | |
| SCHEMBL3395166 | 0.84 | AKR1B1 (0.50) | AKR1B1CYSLTR2CYSLTR1TDP1PTGS2 | |
| SCHEMBL2554055 | 0.81 | AKR1B1 (0.55) | AKR1B1TDP1PTGS2BCAT2CXCL8 | |
| SCHEMBL9276125 | 0.80 | GABRA1 (0.41) | CYSLTR2CYSLTR1KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL10582878 | 0.79 | AKR1B1 (0.53) | AKR1B1TDP1PTGS2BCAT2CXCL8 | |
| SCHEMBL3383898 | 0.79 | AKR1B1 (0.57) | AKR1B1TDP1PTGS2BCAT2CXCL8 | |
| SCHEMBL11669660 | 0.78 | AKR1B1 (0.52) | AKR1B1TDP1PTGS2BCAT2CXCL8 | |
| SCHEMBL2004084 | 0.78 | AKR1B1 (0.52) | AKR1B1TDP1PTGS2BCAT2CXCL8 | |
| SCHEMBL18301679 | 0.77 | AKR1B1 (0.55) | AKR1B1TDP1PTGS2BCAT2CXCL8 | |
| SCHEMBL29718755 | 0.77 | AKR1B1 (0.55) | AKR1B1TDP1PTGS2BCAT2CXCL8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946170-B8 | DICLOFENAC FOR THE TREATMENT OF VASCULOPATHIES | GLYCADIA INC (US) | 2005-12-07 | — | — | EP | disclosed |
| EP-0946170-B1 | DICLOFENAC FOR THE TREATMENT OF VASCULOPATHIES | EXOCELL INC (US) | 2005-10-12 | — | — | EP | disclosed |
| EP-0946170-A4 | INHIBITION OF PROTEIN GLYCATION AND PREVENTION OF VASCULOPATHY | EXOCELL INC (US) | 2002-03-20 | — | — | EP | disclosed |
| EP-0946170-A1 | INHIBITION OF PROTEIN GLYCATION AND PREVENTION OF VASCULOPATHY | EXOCELL, INC. (US) | 1999-10-06 | — | — | EP | disclosed |
| WO-1997029746-A1 | INHIBITION OF PROTEIN GLYCATION AND PREVENTION OF VASCULOPATHY | EXOCELL, INC. (US) | 1997-08-21 | — | — | WO | disclosed |