Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.39 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.39 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6258639 | 0.84 | AKR1B1 (0.52) | AKR1B1TDP1PTGS2BCAT2CYSLTR2 | |
| SCHEMBL6546270 | 0.83 | HTR2A (0.45) | TDP1LMNAPOLBCYP2D6MEN1 | |
| SCHEMBL8086649 | 0.82 | TSHR (0.53) | AKR1B1TDP1PTGS2BCAT2CYSLTR2 | |
| SCHEMBL396915 | 0.82 | AKR1B1 (0.50) | AKR1B1TDP1PTGS2CYP2D6KMT2A | |
| SCHEMBL2554055 | 0.79 | AKR1B1 (0.55) | AKR1B1TDP1LMNAPTGS2KMT2A | |
| SCHEMBL12506237 | 0.79 | HTR2A (0.45) | TDP1LMNAPOLBCYSLTR2CYSLTR1 | |
| Hydrochloric Acid SCHEMBL10582878 | 0.78 | AKR1B1 (0.53) | AKR1B1TDP1LMNAPTGS2KMT2A | |
| SCHEMBL3383898 | 0.77 | AKR1B1 (0.57) | AKR1B1TDP1PTGS2BCAT2CXCL8 | |
| SCHEMBL2004084 | 0.76 | AKR1B1 (0.52) | AKR1B1TDP1PTGS2BCAT2CXCL8 | |
| SCHEMBL11669660 | 0.76 | AKR1B1 (0.52) | AKR1B1TDP1PTGS2BCAT2CXCL8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8569013-B2 | Penicillin-G acylases | CODEXIS, INC. (US) | 2013-10-29 | — | — | US | disclosed |
| US-20120270282-A1 | PENICILLIN-G ACYLASES | CODEXIS, INC. (US) | 2012-10-25 | — | — | US | disclosed |
| US-8247192-B2 | Penicillin-G acylases | CODEXIS, INC. (US) | 2012-08-21 | — | — | US | disclosed |
| US-20100143968-A1 | PENICILLIN-G ACYLASES | CODEXIS, INC. (US) | 2010-06-10 | — | — | US | disclosed |
| WO-2010054319-A2 | PENICILLIN-G ACYLASES | CODEXIS, INC. (US) | 2010-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120270282-A1 | PENICILLIN-G ACYLASES | PGLS, PNP, NAAA | AKR1B1 2523/4885TDP1 406/4885LMNA 3603/4885 |
| US-20100143968-A1 | PENICILLIN-G ACYLASES | PGLS, PNP, NAAA | AKR1B1 2523/4885TDP1 406/4885LMNA 3603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.